Global transcriptome profiling of mild relapsing remitting versus primary progressive Multiple Sclerosis

ConclusionOur analyses show significant differences between mRRMS and PPMS gene expression. Surprisingly, the differentially expressed genes are mostly involved in immunological and inflammatory pathways, suggesting that the difference in MS phenotypes is caused primarily by a difference in immune responses. It should be kept in mind that our analyses were in peripheral blood only, and that the observed differences in inflammatory pathways may be a substrate of the analysed tissue. Further research into gene expression differences between disease courses including analyses in CNS tissue are warranted.This article is protected by copyright. All rights reserved.

Source: European Journal of Neurology - January 1, 2018 Category: Neurology Authors: Marcus W. Koch, Yaroslav Ilnytskyy, Andrey Golubov, Luanne M. Metz, V.Wee Yong, Olga Kovalchuk Tags: Original Article Source Type: research