GSTP1 methylation in cancer: a liquid biopsy biomarker?

GSTP1 methylation in cancer: a liquid biopsy biomarker? Clin Chem Lab Med. 2018 Jan 06;: Authors: Gurioli G, Martignano F, Salvi S, Costantini M, Gunelli R, Casadio V Abstract The coding region of GSTP1 gene is preceded by a large CpG-rich region that is frequently affected by methylation. In many cancer types, GSTP1 is affected by hypermethylation and, as a consequence, it has a low expression. The aim of this review is to give an overview on GSTP1 methylation studies with a special focus on liquid biopsy, thus to summarize methods, results, sample types, different diseases, to have a complete information regarding this promising epigenetic biomarker. We used all the most valuable scientific search engines (PubMed, Medline, Scopus and Web of Science) searching the following keywords: GSTP1, methylation, cancer, urine, serum, plasma and blood. GSTP1 is a largely investigated tissue biomarker in several malignancies such as prostate, breast, lung and hepatocellular carcinoma with good performances especially for diagnostic purposes. As a liquid biopsy biomarker, it has been mainly investigated in prostate cancer (PCa) where it showed a high specificity but a low sensitivity; thus, it is recommended in combination with other biomarkers. Despite the large number of published papers and the promising results, GSTP1 has not yet entered the clinical practice even for PCa diagnosis. For this reason, further large and prospective studies are needed to validate t...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin Chem Lab Med Source Type: research

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Publication date: Available online 7 July 2018Source: SteroidsAuthor(s): Nguyen Hoai Nam, Ninh Thi Ngoc, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Van Thanh, Do Thi Thao, Do Cong Thung, Phan Van Kiem, Chau Van MinhAbstractUsing various chromatographic separations, seventeen steroids including seven new compounds, verrucorosteroids A−F (1−6) and verrucorosterone (7), were isolated from the Vietnamese gorgonian Verrucella corona. Their structures were elucidated by spectroscopic analysis, including HR QTOF MS, 1D and 2D NMR. Among isolates, verrucorosterone (7), 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Conclusions:ANN of short time acquisition was generally acceptable in 75% and 50% of the scan time. As for BSI and HsN, quantitative indices of short time acquisition mostly corresponded to that of the 100% image even in 10% of the scan time. Whole body CZT camera has the potential to reduce scan time or injection dose of the radioisotope to evaluate the BSI of bone scan.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Musculoskeletal Source Type: research
Conclusions: Our data show that the short time acquisition bone scan images simulated by Poisson resampling were closely correlated with those by list mode when BSI was used as a quantitative index of abnormality. Thus, Poisson resampling provides a reliable alternative to true short time acquisition images.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Tech Papers IV: Instrumentation & amp; Data Analysis Technoloigst Abstracts Source Type: research
AbstractObjectiveTo examine the effect of the aqueous extract ofLigustrum robustum on tumor growthin vitro andin vivo and explore the possible molecular mechanisms.MethodsInin vitro study, cell viabilities of human cervical carcinoma cells (HeLa), human breast cancer cells (MCF-7), human prostate cancer cells (PC-3), human hepatoma cells (7721) and human colon carcinoma cells (SW480) were evaluated with cell counting kit-8. ForL. robustum-treated Hela cells, early or late apoptosis were evaluated by annexin V/PI staining. Mitochondrial membrane potential was measured by staining cells with JC-1. Apoptosis was monitored by ...
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
We present the case of a 30-year-old woman with triple-negative bilateral breast carcinoma who underwent bilateral mastectomy, chemotherapy, and radiotherapy. She developed a left chest wall and liver recurrence after primary therapy. Her recurrent disease was also triple-negative. In view of the known poor prognosis and very limited therapeutic options, we performed 68Ga-PSMA PET/CT scan to explore the possibility of PSMA-based therapy as a future option after exhausting standard-of-care treatments.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Authors: Cui Z, Li H, Liang F, Mu C, Mu Y, Zhang X, Liu J Abstract WD repeat domain 5 (WDR5) serves an important role in various biological functions through the epigenetic regulation of gene transcription. Aberrant expression of WDR5 has been observed in various types of human cancer, including prostate cancer, breast cancer and leukemia. However, the role of WDR5 expression and its clinical implications in hepatocellular carcinoma (HCC) remain largely unknown. The present study investigated the WDR5 expression pattern in HCC. It was demonstrated that the mRNA and protein levels of WDR5 were upregulated in HCC can...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Conclusions: Smoking increased the overall risk of cancer in primary care practices in the UK. In addition, smoking was predominantly positively and less frequently negatively associated with numerous specific cancers. PMID: 29707117 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Wang Y, Lan GB, Peng FH, Xie XB Abstract Renal transplantation is associated with an increased risk of cancers at multiple sites; however, the relationships between increased cancer risk and participant characteristics remain unclear. We searched PubMed, Embase, and the Cochrane Library to identify prospective observational studies performed up to July 2017. Totally 11 prospective studies reported data on 79,988 renal transplant recipients were included. Renal transplant recipients were found to display a higher risk of all cancers (standard incidence ratio [SIR]: 2.89; 95% CI: 2.13-3.91; P
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
heng Luo Kai Chen SET7, serving as the only histone methyltransferase that monomethylates ‘Lys-4’ of histone H3, has been proved to function as a key regulator in diverse biological processes, such as cell proliferation, transcriptional network regulation in embryonic stem cell, cell cycle control, protein stability, heart morphogenesis and development. What′s more, SET7 is involved inthe pathogenesis of alopecia aerate, breast cancer, tumor and cancer progression, atherosclerosis in human carotid plaques, chronic renal diseases, diabetes, obesity, ovarian cancer, prostate cancer, hepatocellular car...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
s The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This special issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outl...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Editorial Source Type: research
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