Novel homeodomain transcription factor Nkx2.2 in the brain tumor development.

CONCLUSION: Shh pathway play vital role in oligodendrocytes differentiation and Nkx2.2 transcription factor is essential for o ligodendrocytes differentiation and maturation. Intriguingly, down regulation of Nkx2.2 transcription factor with aberrant Shh signaling pathway is reported in glioma samples. So here suggest that Nkx2.2 expression pattern could be used as a potential biomarker for the early diagnosis of glioma. PMID: 29295693 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29295693?dopt=Abstract

Source: Current Cancer Drug Targets - January 1, 2018 Category: Cancer & Oncology Authors: Mariyath MP, Shahi MH, Farheen S, Tayyab M, Khanam N, Ali A Tags: Curr Cancer Drug Targets Source Type: research