GSE101096 Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: The role of miR-497 in epithelial to mesenchymal transition of keratinocytes

Contributors : Adi Mizrahi ; Aviv Barzilai ; Devorah Gur-Wahnon ; Iddo Z Ben-Dov ; Shayna Glassberg ; Tal Meningher ; Einat Elharar ; Moamen Masalha ; Jasmine Jacob-Hirsch ; Hilla Tabibian-Keissar ; Iris Barshack ; Jason Roszik ; Raya Leibowitz-Amit ; Yechezkel Sidi ; Dror AvniSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe found that miR-497 expression decrease in cSCC biopsies and cell lines compare to normal skin biopsies or normal keratinocytes cell. To understand in role lost expression of miR-497 might have in tumorigenesis of keratinocytes, we aimed to fine possible biochemical pathways and possible targets of miR-497 in cSCC. In order do so, we over expressed miR-497 in cSCC and used microarrays to fine global gene expression effected by miR-497.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research