Endonovo Therapeutics finally buys Rio Grande Neuroscience assets for nearly $5m

Nearly a year-and-a-half after their planned $22 million merger fell through,Endonovo Therapeutics (OTC:ENDV) said last week that it acquired intellectual property and assets from Rio Grande Neurosciences for $4.5 million. Rio Grande in August 2016 backed out of deal with Endonovo after seeking to renegotiate its terms when Steven Gluckstern, chairman &CEO of Santa Fe-based Rio Grande, dissolved a binding letter of intent. Los Angeles-based Endonovo, which had raised $10 million to fund the $21.5 million buyout, was to have put up $1.5 million in cash, another $15 million in ENDV shares and $5 million worth of warrants for Rio Grande. Rio Grande has an FDA-cleared and CE-mMarked device for treating pain and edema using pulsed electromagnetic fields and a multi-coil repetitive transcranial magnetic stimulation device with a pending 510(k) application. The new deal, executed Dec. 22, saw Endonovo put up $3 million in cash plus a $1.5 million promissory note due Nov. 30, 2018. It came after Rio Grande and Endonovo settled their dispute over the previous deal, with Rio Grande ponying up $150,000 to put the matter to rest, Endonovo said. The company said it raised the $3 million payment by issuing $700,000 worth of new preferred stock, a $1.8 million convertible note to Eagle Equities and “the application of available company funds.” “We intend to initiate and fund both currently planned and all futu...
Source: Mass Device - Category: Medical Devices Authors: Tags: Mergers & Acquisitions Wall Street Beat Source Type: news

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Conclusion: The CCS system improved compliance in both stroke and general neurologists compared with TOAST. This suggests that the automatic, evidence-based, easily reproducible CCS system was superior to the TOAST system. PMID: 30764594 [PubMed - in process]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
The objectives were divided into four groups: 43°C heat stress combined with lipopolysaccharide (LPS) group, 43°C heat stress group, LPS group, and control group. There were 10 cases in each group. An enzyme-linked immunosorbent assay (ELISA) test was used to measure the concentrations of supernatant inflammatory mediators (tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-10 (IL-10)). After loaded by 2,7-Dichlorodi-hydrofluorescein-diacetate (DCFHDA) fluorescent probe, intracellular reactive oxygen species (ROS) levels were determined by a flow cytometry. After fluorescent...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
Abstract BACKGROUND: Ticagrelor has been widely accepted in clinical practice for treatment of acute myocardial infarction (AMI), however its clinical safety and efficacy have not been revealed sufficiently in Asian populations. METHODS AND RESULTS: Among a total 20,270 patients (age
Source: Journal of Cardiology - Category: Cardiology Authors: Tags: J Cardiol Source Type: research
BRIAN MCFADDEN health latest: Dancing on Ice star Brian McFadden is battling a bad back after sustaining an injury during rehearsals for the ITV show. How do you treat back pain?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study collected and analyzed the data of medical records of pain clinic in Tibet Autonomous Region People's Hospital from September 2017 to August 2018. The results showed that the total amounts of patients visiting pain clinic were very small, the most common pain diseases were postherpetic neuralgia and sciatica, and more female patients visited the pain clinic than male patients. All these results indicate that the hospital and government need to pay more attention to the development and promotion of pain medicine in Tibet to make Tibetans being accessed to high-quality pain clinic service. PMID: 30766644 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Publication date: March 2019Source: International Journal of Industrial Ergonomics, Volume 70Author(s): Hamed Asadi, Denny Yu, John H. MottAbstractAircraft maintenance workers are exposed to high injury rates, but risk exposures are difficult to measure and task contributors are difficult to identify due to the wide variety of parts and irregularity of jobs in this industry. Subjective metrics, posture assessments, and lifting analyses were collected from 235 employees from five work areas in aviation maintenance, repair and overhaul (MRO) facilities to measure ergonomic risk factors and identify task factors contributing ...
Source: International Journal of Industrial Ergonomics - Category: Occupational Health Source Type: research
Authors: Brignardello-Petersen R PMID: 30770104 [PubMed - as supplied by publisher]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
As we enjoy this touching drama of family reconciliation, it's time to remind ourselves of something so glaringly obvious that we haven't even noticed it. Presumably the sons of Israel all have wives and daughters, but they might as well not exist. Only men are worth noticing and naming, only men act in this world. It is a patriarchal society.Keep in mind this is fiction. It was written in the fifth century BC, long after it supposedly happened. It has an essential function in the plot of the Torah, the founding myth of the Jewish people. We'll get to that in due course. The story becomes rather tedious at this point and w...
Source: Stayin' Alive - Category: American Health Source Type: blogs
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: ARAT-2 appears to be valid and a responsive short assessment for upper extremity activity capacity, and suitable for use in the acute stage after stroke. However, when the highest score has been reached, the assessment needs to be complemented with other instruments. PMID: 30767025 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
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