Differential Associations of Distinct Forms of Childhood Adversity With Neurobehavioral Measures of Reward Processing: A Developmental Pathway to Depression

Childhood adversity is associated with altered reward processing, but little is known about whether this varies across distinct types of adversity. In a sample of 94 children (6–19 years), we investigated whether experiences of material deprivation, emotional deprivation, and trauma have differential associations with reward‐related behavior and white matter microstructure in tracts involved in reward processing. Material deprivation (food insecurity), but not emotional deprivation or trauma, was associated with poor reward performance. Adversity‐related influences on the integrity of white matter microstructure in frontostriatal tracts varied across childhood adversity types, and reductions in frontostriatal white matter integrity mediated the association of food insecurity with depressive symptoms. These findings document distinct behavioral and neurodevelopmental consequences of specific forms of adversity that have implications for psychopathology risk.
Source: Child Development - Category: Child Development Authors: Tags: Empirical Article Source Type: research

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CONCLUSION: Women receiving perinatal depression treatment experience unique parenting challenges and desire parenting support. Healthcare providers caring for these women should be mindful of their patients' parenting needs. Future research should explore ways to integrate parenting interventions with depression treatments. Mother-infant interaction is a key determinant of optimal infant development and integrating parenting support with perinatal depression treatments can have significant public health impact. PMID: 30111227 [PubMed - as supplied by publisher]
Source: Journal of Psychosomatic Obstetrics and Gynaecology - Category: OBGYN Tags: J Psychosom Obstet Gynaecol Source Type: research
Publication date: Available online 16 August 2018Source: Journal of Anxiety DisordersAuthor(s): Ateka A. Contractor, Talya Greene, Megan Dolan, Jon D. ElhaiAbstractCo-occurring posttraumatic stress disorder (PTSD) and depression following traumatic experiences are cumulatively associated with functional impairment. To examine mechanisms for the PTSD-depression comorbidity, we investigated their cluster-level associations. Using data obtained from Amazon’s Mechanical Turk platform, 368 trauma-exposed participants were split into two subsamples: those with (n = 163) and without (n = 185) pro...
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
Publication date: Available online 16 August 2018Source: NeuronAuthor(s): Wataru Kakegawa, Akira Katoh, Sakae Narumi, Eriko Miura, Junko Motohashi, Akiyo Takahashi, Kazuhisa Kohda, Yugo Fukazawa, Michisuke Yuzaki, Shinji MatsudaSummaryLong-term depression (LTD) of AMPA-type glutamate receptor (AMPA receptor)-mediated synaptic transmission has been proposed as a cellular substrate for learning and memory. Although activity-induced AMPA receptor endocytosis is believed to underlie LTD, it remains largely unclear whether LTD and AMPA receptor endocytosis at specific synapses are causally linked to learning and memory in ...
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: Available online 16 August 2018Source: NeuronAuthor(s): Kenneth J. Burke, Caroline M. Keeshen, Kevin J. BenderSummaryNeuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are often considered a requirement for defining a presynaptic site of action. Nevertheless, some synapses exhibit non-canonical forms of neuromodulation, where release probability ...
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: Available online 16 August 2018Source: NeuronAuthor(s): Matthew J.M. Rowan, Audrey Bonnan, Ke Zhang, Samantha B. Amat, Chikako Kikuchi, Hiroki Taniguchi, George J. Augustine, Jason M. ChristieSummaryPurkinje cell dendrites convert excitatory climbing fiber input into signals that instruct plasticity and motor learning. Modulation of instructive signaling may increase the range in which learning is encoded, yet the mechanisms that allow for this are poorly understood. We found that optogenetic activation of molecular layer interneurons (MLIs) that inhibit Purkinje cells suppressed climbing-fiber-evoked den...
Source: Neuron - Category: Neuroscience Source Type: research
AbstractTherapeutic presence refers to the capacity to bring one ’s whole self into encounters with clients by being present on multiple levels: physically, emotionally, cognitively, and spiritually. It has been suggested that mindfulness influences therapeutic presence in various ways, for example through the fostering of self-compassion or through the reducti on of anxiety and depression symptoms in the psychologist. The main objective of this research is to examine the mediating roles of self-compassion and psychological distress in the relationship between mindfulness and therapeutic presence. Questionnaires were...
Source: Mindfulness - Category: Psychiatry & Psychology Source Type: research
Acta Psychiatrica Scandinavica,Volume 138, Issue 3, Page 274-274, September 2018.
Source: Acta Psychiatrica Scandinavica - Category: Psychiatry Authors: Source Type: research
Journal of Neurochemistry, EarlyView.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Source Type: research
Psycho-Oncology,Volume 0, Issue ja, -Not available-.
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Source Type: research
For decades, Tim Lennon repressed memories of the childhood abuse he says he suffered at the hands of a priest. It wasn’t until 1995, when Lennon was in his late 40s and living in San Francisco, that he stumbled across information about clergy sexual abuse and felt decades-old memories come flooding back. “I said, ‘Oh my god, that happened to me,'” Lennon remembers. But even that moment, he says, didn’t prepare him for the memories that resurfaced in 2010 — an avalanche that he believes was triggered by his twin daughters turning 12, the age around which he says he was raped by a priest....
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Mental Health/Psychology onetime Source Type: news
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