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Differential Associations of Distinct Forms of Childhood Adversity With Neurobehavioral Measures of Reward Processing: A Developmental Pathway to Depression

Childhood adversity is associated with altered reward processing, but little is known about whether this varies across distinct types of adversity. In a sample of 94 children (6–19 years), we investigated whether experiences of material deprivation, emotional deprivation, and trauma have differential associations with reward‐related behavior and white matter microstructure in tracts involved in reward processing. Material deprivation (food insecurity), but not emotional deprivation or trauma, was associated with poor reward performance. Adversity‐related influences on the integrity of white matter microstructure in frontostriatal tracts varied across childhood adversity types, and reductions in frontostriatal white matter integrity mediated the association of food insecurity with depressive symptoms. These findings document distinct behavioral and neurodevelopmental consequences of specific forms of adversity that have implications for psychopathology risk.
Source: Child Development - Category: Child Development Authors: Tags: Empirical Article Source Type: research

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AbstractAs one of the first defenders of innate immune response, neutrophils make a rapid and robust response against infection or harmful agents. While traditionally regarded as suicidal killers that cause collateral tissue damage, recent findings on neutrophil extracellular trap formation, heterogeneity and plasticity and novel reparative functions have expanded our understanding of their diverse roles in health and disease. This review summarizes our current understanding of neutrophil-associated tissue injury, highlighting the emerging roles of neutrophil extracellular traps. This review will also focus on scrutinizing...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
David H. V. Vogel, Katharina Kr ämer, Theresa Schoofs, Christian Kupke, Kai Vogeley
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Heart failure (HF) has been referred to as the cardiovascular epidemic of our time. Understanding the molecular determinants of HF disease progression and mortality risk is of utmost importance. In this issue of the JCI, Zhang et al. uncover an important link between clinical HF mortality risk and a common variant that regulates SCN5A expression through microRNA-dependent (miR-dependent)mechanisms. They also demonstrate that haploinsufficiency of SCN5A is associated with increased accumulation of reactive oxygen species (ROS) in a genetically engineered murine model. Their data suggest that even modest depression of SCN5A ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
This study was done to examine whether depression, self-esteem, and social support influence suicidal ideation among college students. Methods Using a correlation study design, participants were recruited from two universities selected by conve...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: career confidence featured self improvement success best happiness best self-improvement blogs pickthebrain psychology Source Type: blogs
Kostas Patas, Anne Willing, C üneyt Demiralay, Jan Broder Engler, Andreea Lupu, Caren Ramien, Tobias Schäfer, Christian Gach, Laura Stumm, Kenneth Chan, Marissa Vignali, Petra C. Arck, Manuel A. Friese, Ole Pless, Klaus Wiedemann, Agorastos Agorastos, Stefan M. Gold
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Trials - Category: Research Source Type: clinical trials
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Peer Support Relationships Self-Help Stigma Video acceptance Apology Bipolar Disorder Blame destigmatization Mental Illness Responsibility Self-Esteem Shame trust Source Type: blogs
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Source: AAFP News - Category: Primary Care Source Type: news
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