The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-{beta}TrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis

This study provides a mechanistic understanding of how MCPH1 controls neural stem cell fate and brain development.

Source: EMBO Journal - December 15, 2017 Category: Molecular Biology Authors: Liu, X., Zong, W., Li, T., Wang, Y., Xu, X., Zhou, Z.-W., Wang, Z.-Q. Tags: Cell Cycle, Neuroscience Articles Source Type: research