Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice

Conclusions:
Enhanced systolic function and reduced diastolic function indicates early ventricular remodeling in obese and diabetic mice. They have SAN dysfunction, and adrenoreceptor stimulation triggers cardiac arrhythmia originating in the SAN. Thus, dysfunction of the intrinsic cardiac pacemaker and remodeling of the autonomic nervous system may conspire to increase cardiac mortality in diabetic patients.

Source: Cardiovascular Diabetology - August 12, 2014 Category: Cardiology Authors: Ewa SoltysinskaTobias SpeerschneiderSine WintherMorten Thomsen Source Type: research