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IJERPH, Vol. 14, Pages 1518: Exploring Determinants of Spatial Variations in the Dengue Fever Epidemic Using Geographically Weighted Regression Model: A Case Study in the Joint Guangzhou-Foshan Area, China, 2014

In this study, the neighboring Guangzhou and Foshan (GF) cities were considered as a joint area for characterizing the spatial variations in the 2014 DF epidemic at various grid levels from 1 × 1 km2 to 6 × 6 km2. On an appropriate scale, geographically weighted regression (GWR) models were employed to interpret the influences of socioeconomic and environmental factors on this epidemic across the GF area. DF transmissions in Guangzhou and Foshan cities presented synchronous temporal changes and spatial expansions during the main epidemic months. Across the GF area, this epidemic was obviously spatially featured at various grid levels, especially on the 2 × 2 km2 scale. Its spatial variations were relatively sufficiently explained by population size, road density, and economic status integrated in the GWR model with the lowest Akaike Information Criterion (AICc = 5227.97) and highest adjusted R square (0.732) values. These results indicated that these three socioeconomic factors acted as geographical determinants of spatial variability of the 2014 DF epidemic across the joint GF area, although some other potential factors should be added to improve the explaining the spatial variations in the central zones. This work improves our understanding of the effects of socioeconomic conditions on the spatial variations in this epidemic and helps local hygienic authorities to make targeted joint interventions for preventing and controlling this epidemic across the GF ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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ConclusionsDengue patients older than 65 and those with severe and non-specific signs and symptoms at the time of reporting were at a higher risk of ICU admission and mortality. First-line healthcare providers need to be aware of the varied presentations between the different age groups to allow early diagnosis and in-time management, which would prevent ICU admissions and fatalities in dengue patients.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This study was based upon a small number of cases and ultrasound detection rather than births. Seven cases of microcephaly were reported above background, but only one of them was a birth; the others were detected by ultrasound. The high rate of ultrasound detection is not consistent with observations by ultrasound of microcephaly in other countries, including Colombia. We use the model for French Polynesia as a reference model for comparison with other data in order to clarify which data is or is not consistent with that model. We note that this rate is about 100 times larger than the minimum reported background rate for ...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
FINDINGSA new study demonstrates that outbreaks of mosquito-borne viruses Zika and Chikungunya generally occur about three weeks after heavy rainfall.Researchers also found that Chikungunya will predominate over Zika when both circulate at the same time, because Chikungunya has a shorter incubation period — just two days, versus 10 days for Zika. The latter finding explains why a late-2015 Zika epidemic in Rio de Janeiro ended while the number of Chikungunya cases increased in February 2016.BACKGROUNDViruses transmitted by insects can lead to serious health repercussions. Zika is linked to birth defects, and up to 1 ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
AbstractDengue virus is endemic in French Guiana with occurrence of cyclical outbreaks. There is a need for rapid tests allowing dengue laboratory diagnosis in healthcare centers scattered throughout this wide Amazonian territory. Our objective was to evaluate the real-life performance of the SD BIOLINE Dengue Duo (IgG/IgM  + NS1 Ag) rapid test (RDT) during the 2012–2013 dengue epidemics. The RDT was evaluated in parallel with routine laboratory tests, PlateliaTM Dengue NS1 Ag and Focus Diagnostics Dengue Fever Virus IgM Capture DxSelect. A total of 3,347 patients with suspected dengue acute infection were ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
The objective of this study was to assess the mortality associated with chikungunya epidemics in Brazil by comparing the mortality of pre-chikungunya with mortality during chikungunya epidemics2,3. Methods We studied the 3 Brazilian states with higher chikungunya incidence rates (IR), Pernambuco (9,410,772 inhabitants), Rio Grande do Norte (3,474,998 inhabitants), and Bahia (15,498,733 inhabitants)5. Bahia is the largest and most populated state, with a heterogeneous incidence of chikungunya, and therefore we analyzed separately each one of 9 administrative regions of Bahia. We retrospectively analyzed anonymous, publicly...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
Burkina Faso has been experiencing an epidemic of dengue fever since week 31 of 2017 (week ending on 6 August). WHO officially declared the outbreak on 28 September 2017.
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Abstract Global immunization efforts to date have heavily focused on infants and children, with noted success on public health. Healthy adolescents and adults contribute to the economic growth and development of countries but efforts to ensure vaccine coverage for these groups receive inadequate global attention and resources. Emerging epidemics for a number of infectious diseases including Ebola, Zika, dengue, malaria and the continuing epidemics of tuberculosis and several sexually transmitted infections, including HIV, HPV and Hepatitis B, have high incidence and prevalence in adolescents and adults. New vaccin...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
ConclusionsIn 2015 –2016 in the Recife Metropolitan Region, we detected the tail end of a Zika epidemic, which was displaced by a chikungunya epidemic. Few dengue cases were identified despite a high number of official dengue notifications in the area during this period. We show here important epidemiological featur es of these cases.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
In 1780 Benjamin Rush —a physician and a founding father of the USA—noted the appearance of an alarming epidemic in his home city of Philadelphia. Rush was familiar with the intricate nosologies of fevers generated by his late-Enlightenment colleagues, but this outbreak had a distinctive symptom: “the pains which a ccompanied this fever were exquisitely severe in the head, back and limbs”. He deployed the usual purging, soothing, and strengthening remedies, but with little success, and he observed that “its general name among all classes of people was the break-bone fever”.
Source: LANCET - Category: General Medicine Authors: Tags: Perspectives Source Type: research
Conclusion and significanceThe proposed SVR model achieved a superior performance in comparison with other forecasting techniques assessed in this study. The findings can help the government and community respond early to dengue epidemics.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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