Recommendations for the use of immunoglobulin therapy for immunomodulation and antibody replacement.
Recommendations for the use of immunoglobulin therapy for immunomodulation and antibody replacement. S Afr Med J. 2014 Sep 29;104(11):7306 Authors: Peter JG, Heckmann JM, Novitzky N Abstract Polyvalent immunoglobin, derived from pooled human plasma, can be administered via the intravenous, subcutaneous or intramuscular route. Therapy is standard of care in the treatment of a number of immune-mediated pathologies across disciplines. By volume, the majority is used in neurology (~40%). In primary immunodeficiencies, therapy reconstitutes humoral immunity at replacement doses (0.4 - 0.6 g/kg/month), decreasing infections, and is usually lifelong. However, high doses, usually 2 g/kg total dose over five days, are required for immunomodulation in autoimmune and inflammatory indications. A high-quality evidence base supports use in primary antibody failure, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, acute idiopathic thrombocytopenia, Kawasaki disease andimmunobullous diseases. Low-quality evidence shows benefit in many other uncommon autoimmune and immunodeficient conditions.In South Africa, use of immunoglobulin therapy is restricted and, given the cost involved, will likely remain so. Therefore, the incremental benefit over other forms of immunosuppression, particularly corticosteroids, must be assessed carefully on a case-by-case basis. In most cases, therapy will be second-line or 'rescue...
A group of moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed.
Publication date: Available online 31 March 2020Source: Preventive Veterinary MedicineAuthor(s): Tiny Motlatso Hlokwe, Marcia Mogano Ratanna
CONCLUSION: Our results indicated that MSC-secretome had DPP-IV/CD26 and APN/CD13 activity. The DPP-IV/CD26 activity was decreased following stimulation of MSCs by toll-like receptor 4 agonist. Further studies are needed to reveal the possible contribution of DPP-IV/CD26 and APN/CD13 in the anti-inflammatory functions of MSC-CM. PMID: 32224540 [PubMed - in process]
US has one 1 in 5 cases globally; global cases pass 860,000; record daily fatalities in UK, France, Spain and RussiaUS coronavirus - latest updatesUK coronavirus – live updatesLatest developments at a glanceThe most extreme lockdown controls around the worldSee all our coronavirus coverage3.34pmBSTAbout 8 million more people in the Arab world will be plunged into poverty by the economic spasm caused by the Covid-19 crisis, leading to a likely 2 million becoming undernourished, the UN ’s Economic and Social Commission for Western Asia says.ESCWA said that a lack of social security in many Arab countries will lea...
[Daily Maverick] South African researchers are poised to start enrolling patients in an international clinical trial launched by the World Health Organisation which will compare the safety and effectiveness of four different drugs or drug combinations against Covid-19.
[spotlight] South African researchers are poised to start enrolling patients in an international clinical trial launched by the World Health Organization (WHO) which will compare the safety and effectiveness of four different drugs or drug combinations against COVID-19.
[News24Wire] The death of Professor Gita Ramjee who dedicated her life's work to the prevention of one virus - HIV - has left colleagues and friends gutted.
Uptake of contraceptive implants has declined in South Africa since their introduction in 2014, with side effects and inadequate health provider training cited as primary contributors underlying a poor community perception of implants. In this paper we exp...
[Swazi Media] The Swaziland (eSwatini) Health Ministry has received 324 results of coronavirus tests sent to South Africa in total since 15 March 2020.