Paraoxonase-1: Characteristics and role in atherosclerosis and carotid artery disease.

Paraoxonase-1: Characteristics and role in atherosclerosis and carotid artery disease.
Curr Vasc Pharmacol. 2017 Nov 29;:
Authors: Lioudaki S, Verikokos C, Kouraklis G, Ioannou C, Chatziioannou E, Perrea D, Klonaris C
Abstract
Paraoxonase-1 (PON-1) is a calcium-dependent enzyme that is synthesized in the liver and then secreted in blood where it is bound to high density lipoprotein(HDL). PON-1 is a hydrolase with a wide range of substrates, including lipid peroxides. It is considered responsible for many of the antiatherogenic properties of HDL. PON-1 prevents low density lipoprotein (LDL) oxidation, a process that is considered to contribute to the initiation and development of atherosclerosis. PON-1 activity and levels areinfluenced by gene polymorphisms; of the 2 common variants, one is in position 192 (Q192R) and one in position 55 (M55L). Also, many drugs affect PON-1 activity. The role of PON-1 in carotid atherosclerosis is inconsistent. Some studies show an association of PON-1 polymorphisms with carotid plaque formation, whereas others do not. The aim of this review is to summarize the characteristics of PON-1,its interactions with drugs and its role in atherosclerosis and especially its relationship with carotid artery disease.
PMID: 29189170 [PubMed - as supplied by publisher]

Source: Current Vascular Pharmacology - November 29, 2017 Category: Drugs & Pharmacology Authors: Lioudaki S, Verikokos C, Kouraklis G, Ioannou C, Chatziioannou E, Perrea D, Klonaris C Tags: Curr Vasc Pharmacol Source Type: research