Semaphorin-3E attenuates neointimal formation via suppressing VSMCs migration and proliferation

ConclusionOur study demonstrates that Sema3E/plexinD1 inhibits proliferation and migration of VSMCs via inactivation of Rap1-AKT signalling pathways. The mutual inhibition between PDGF-BB and Sema3E after vascular injury plays a critical role in the process of neointimal formation.
Source: Cardiovascular Research - Category: Cardiology Source Type: research