The impact of screening method on HLA antibody detection before and after lung transplantation: A prospective pilot study

Despite the development of solid phase Luminex-based assays using human leukocyte antigen (HLA)-coated microbeads, there is significant center variability in the identification of HLA antibodies in lung transplantation. Some institutions screen for the presence of any antibodies and then use single antigen beads (SAB) to determine antibody identity if the pre-screen is positive (the pre-screen method).1 Other centers do not pre-screen, using SAB only.2 SAB, however, are significantly more sensitive than pre-screening.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research