Clinical Outcome Predictors for Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is a group of aggressive B-cell lymphomas displaying heterogeneous outcomes after treatment. Some patients have the slowly progressing disease that does not require immediate treatment, while others have a disease that rapidly progresses despite highly aggressive treatment. A number of prognostic tools have been described to determine whether patients have slow or rapidly progressing diseases, including the mantle cell lymphoma International Prognostic Index (MIPI) and biomarkers, such as KI-67.Researchers have discovered a novel method of predicting a MCL patient ’s overall survival prognosis (poor, intermediate, or good) by measuring the gene expression profile of a specific subset of biomarkers from a biopsy and using a set of statistical algorithms to analyze the results and produce a “survival score”. The survival score enables a physician to dete rmine the best course of treatment, such as a less aggressive or more aggressive treatment protocol or an experimental treatment that would be the most beneficial for an MCL patient.IC: NCINIH Ref. No.: E-131-2016/0Advantages: Does not require fresh frozen samples, utilizes formalin-fixed paraffin-embedded (FFPE) samplesIn contrast to current KI-67 assay, the subject technology is reproducibleApplications: Mantle cell lymphoma prognostic toolProvider Technology ID: 3209Updated On: Nov 21, 2017Date Published: Tuesday, November 21, 2017Provider Classifications:&n...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research