Gastroesophageal Reflux Disease.

Gastroesophageal Reflux Disease. Prim Care. 2017 Dec;44(4):561-573 Authors: Kellerman R, Kintanar T Abstract Gastroesophageal reflux disease (GERD) is a gastrointestinal motility disorder that results from the reflux of stomach contents into the esophagus or oral cavity resulting in symptoms or complications. The typical symptoms of GERD are heartburn and regurgitation of gastric contents into the oropharynx. GERD affects quality of life and may cause erosive esophagitis, esophageal strictures, and Barrett esophagus, a precursor to esophageal adenocarcinoma. GERD is a clinical diagnosis and is most effectively treated with proton-pump inhibitors (PPIs). Long-term use of PPIs is associated with bone fractures, chronic renal disease, acute renal disease, community-acquired pneumonia, and Clostridium difficile intestinal infection. PMID: 29132520 [PubMed - in process]
Source: Primary Care - Category: Primary Care Authors: Tags: Prim Care Source Type: research

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Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Yoo Jin Lee, Harim Oh, Eojin Kim, Bokyung Ahn, Jeong Hyeon Lee, Youngseok Lee, Yang Seok Chae, Sung Gu Kang, Chul Hwan KimAbstractHOXA transcript at the distal tip (HOTTIP) is a long noncoding RNA (lncRNA), which is>200 nucleotides in length. HOTTIP expression has been demonstrated to play a crucial oncogenic role in cancer pathogenesis, and is said to be associated with poor human cancer prognosis. In prostate cancer, HOTTIP has been identified as an oncogene, but its clinicopathologic significance remains unclear. A...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 September 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Serhat BorABSTRACT:The pathogenesis of gastroesophageal reflux disease has been explained by acid-peptic model. However, related with the progress of the diagnostic modalities, another phenotypical group of patients were defined and called “functional disorders of the esophagus”. These patients are important because diagnosis is particularly difficult, co-morbid disorders especially psychiatric diseases are common, proton pump inhibitor response is low, and surgical results are very poor. ...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): James M. Bowen, Robert B. Hopkins, LIFENG Xie, Gord Blackhouse, Daria J. O’reilly
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
The maker of a generic version of Zantac is halting distribution. It comes after an FDA warning about a possible cancer-causing chemical found in Zantac and related heartburn medications. Dr. Jon LaPook explains.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Drug giant conducting its own investigation into traces of a potentially cancer-causing ingredient in heartburn med
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
In this study, a specific and sensitive LC-MS/MS method has been developed and validated, for the quantification of ilaprazole enantiomers in the rat plasma, using R-lansoprazole as the internal standard. The enantioseparation was achieved on a CHIRALPAK AS-RH column (4.6 mm × 150 mm, i.d. 5 μm), with a mobile phase composed of 10 mM ammonium acetate aqueous solution and acetonitrile (60:40, v/v), at a flow-rate of 0.5 mL/min. The method was validated over the concentration range of 0.5–300 ng/mL for both, R- and S -ilaprazole. The lower limit of quantification was 0.5 ng/mL for both enanti...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research
This study aims to design and synthesize Endostatin (ENT)-loaded nanoparticles using Folic acid (FA) as a driver for targeted anti-proliferative chemotherapy in Esophageal Squamous Cell Carcinoma (ESCC). An ionic gelation method was employed to formulate FA-decorated, ENT-loaded nanoparticles, which were tested in vitro on KYSE-30 cells using unbiased stereological approaches. FA-ENT nanoparticles were internalized into ESCC cells with preferential binging to the nucleus and mitochondria for necrotic and apoptotic effects. Nanoparticles showed increased proliferation inhibition of 64.71% and reduced KYSE-30 cell migration ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsOur study data indicated that miR-27b-3p is downregulated by aberrant DNA methylation in GC. In addition, miR-27b-3p suppresses GC cell proliferation, invasion, and migration via negative expression regulation of GSPT1, which could be a potential therapeutic target.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsSST or CXCR4 expression in PAC is clearly of no therapeutic relevance. However, indirect targeting of these tumours via SST3, SST5, or CXCR4 on tumour microvessels may represent a promising additional therapeutic strategy.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Ascorbic acid and retinol palmitate modulatory effect on omeprazole-induced oxidative damage, and the cytogenetic changes in S. cerevisiae and S180 cells. Chem Biol Interact. 2019 Sep 25;311:108776 Authors: Paz MFCJ, Braga AL, de Meneses APM, de Carvalho RM, de Aguiar RPS, Cronemberger LAC, da Silva MBS, de Lima RMT, de Alencar MVOB, Duarte JL, Islam MT, Marcelo de Castro E Sousa J, Mubarak MS, Melo-Cavalcante AAC Abstract Omeprazole (OM), a prototype proton pump inhibitor, oxidizes thiol groups and induces DNA damage. The aim of this study was to evaluate the oxidative effects of omeprazole and its...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
More News: Acid Reflux | Adenocarcinoma | Clostridium Difficile | Erosive Esophagitis | Esophagus Cancer | Gastric (Stomach) Cancer | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Heartburn | Orthopaedics | Pneumonia | Primary Care | Proton Pump Inhibitors PPIs