How harmful can herbal remedies be ? a case of severe acute tubulointerstitial nephritis

We report a biopsy-proven case of AKI due to severe AIN associated with the use of hyponidd tablet in a 60-year-old male with DM and hypertension. As these types of various indigenous compounds are used as home remedies in our country, awareness about the possible adverse effects of these agents among physicians is very important in the early diagnosis and management.
Source: Indian Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research

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Publication date: Available online 22 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. HaefeliAbstractExenatide is the first approved glucagon-like peptide 1 receptor agonist subcutaneously or intramuscularly injected for the treatment of type 2 diabetes mellitus. Typical therapeutic plasma concentrations are in the low pg/mL range therefore requiring ultra-sensitive quantification. To enable the accurate evaluation of pharmacokinetic studies, we established a UPLC-MS/MS assay with a lower limit of quantification (LLOQ) of 5 pg/mL (1.2 pM) using 20...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research
Conclusion: Taken together, these results suggest that SXD maybe alleviate EMT in DN via the inhibition of the TGF-β1/Smad/RUNX3 signaling pathway under hyperglycemic conditions.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Authors: Di Lullo L, Bellasi A, Guastamacchia E, Triggiani V, Ronco C, Lavalle C, Di Iorio BR, Russo D, Cianciolo G, La Manna G, Settembrini S Abstract Diabetes mellitus, with its complications, is one of the major health problems in economically developed countries and its prevalence is constantly increasing. Kidneys and heart involvement represent main comorbidities in diabetic patients often leading to organ's failure. The treatments available until a few years ago are often associated with hypoglycemia, weight gain, gastro-intestinal disorders and other side effects together with serious averse effects on renal...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Authors: De Vecchis R, Paccone A, Di Maio M Abstract BACKGROUND: The MacNew questionnaire in its original version is a diagnostic tool which consists of a number of questions answered on a seven-point scale. Among the multiple possible choices, each marked by a box, the examined patient will have to tick only one. In fact, more than one answer for each proposed question is not allowed, for the formulation of the final score. Global and subscale( physical, social and emotional subscales) scores are computed by dividing the sum of the scores achieved for each individual item by the number of items listed in the quest...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
CONCLUSIONS: Not all interventional procedures result in a mortality benefit. Medical therapy alone increases survival in many cardiac diseases. PMID: 32083425 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Publication date: Available online 22 February 2020Source: Computational and Structural Biotechnology JournalAuthor(s): Abhijit Dasgupta, Gautam K. Bandyopadhyay, Indrani Ray, Keya Bandyopadhyay, Nirmalya Chowdhury, Rajat K. De, Sushil K. MahataAbstractObesity is characterized by a state of chronic, unresolved inflammation in insulin-targeted tissues. Obesity-induced inflammation causes accumulation of proinflammatory macrophages in adipose tissue and liver. Proinflammatory cytokines released from tissue macrophages inhibits insulin sensitivity. Obesity also leads to inflammation-induced endoplasmic reticulum (ER) stress a...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Publication date: 15 May 2020Source: Journal of Molecular Structure, Volume 1208Author(s): M.S. Ganesan, K. Kanmani Raja, K. Narasimhan, S. Murugesan, Banoth Karan KumarAbstractα-amylase enzyme hydrolyses carbohydrate into glucose is known to be an important molecular target for type 2 Diabetes mellitus. In the course of developing α-amylase enzyme inhibitors, we designed, synthesized seventeen novel quinoline bearing proline analogs, subsequently physico-chemical properties of designed analogs were also in silico predicted for their drug likeness evaluation. Synthesized compounds were characterized by spectral...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Authors: Nuotio J, Suvila K, Cheng S, Langén V, Niiranen T Abstract Observational and interventional studies have unequivocally demonstrated that "present", i.e. single-occasion, blood pressure is one of the key determinants of cardiovascular disease risk. Over the past two decades, however, numerous publications have suggested that longitudinal blood pressure data and assessment of long-term blood pressure exposure provide incremental prognostic value over present blood pressure. These studies have used several different indices to quantify the overall exposure to blood pressure, such as time-aver...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Publication date: May 2020Source: Biomedical Signal Processing and Control, Volume 59Author(s): Shaun M. Davidson, Vincent Uyttendaele, Christopher G. Pretty, Jennifer L. Knopp, Thomas Desaive, J. Geoffrey ChaseAbstractObjectiveSafe, effective glycaemic control (GC) requires accurate prediction of future patient insulin sensitivity (SI), balancing the risk of hyper- and hypo-glycaemia. The stochastic targeted (STAR) protocol combines a clinically validated metabolic model and SI metric with a risk-based stochastic approach to optimise patient specific insulin and feed rates. Validated virtual trials comparing a novel 3D st...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Conclusion The elucidation of the function of circRNAs is an emerging field of science with a tremendous potential after previously being dismissed as RNA artifacts. They are ubiquitously expressed and thousands of members have already been identified. This fact only expands their potential to possibly enhance our knowledge to understand the difference between health and disease. Owing to their structure stability and their presence in exosomes circRNAs may also exert their function in an autocrine, paracrine and possible endocrine fashion. In addition, the fact that circRNAs are widely distributed in the cellular compart...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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