Increasing alkali supplementation decreases urinary nitrogen excretion when adjusted for same day nitrogen intake

ConclusionsUrinary N excretion expressed as ratio to same day N intake declined steadily with increasing doses of KHCO3 supplementation from low 1 mmol/kg/day to high 1.5 mmol/kg/day, suggesting a nitrogen-sparing effect. Compared to urinary N excretion alone, this ratio could be a more reasonable measure of muscle protein metabolism in large-scale long-term human studies.Trial registration:Clinicaltrials.gov NCT1475214

http://link.springer.com/10.1007/s00198-017-4196-8

Source: Osteoporosis International - November 14, 2017 Category: Orthopaedics Source Type: research