Improving Neurorepair in Stroke Brain Through Endogenous Neurogenesis-Enhancing Drugs.

Improving Neurorepair in Stroke Brain Through Endogenous Neurogenesis-Enhancing Drugs. Cell Transplant. 2017 Sep;26(9):1596-1600 Authors: Wu KJ, Yu S, Lee JY, Hoffer B, Wang Y Abstract Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone of the adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes that occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs and review the general status of stroke therapeutics in evaluating the field of pharmacotherapy for stroke. PMID: 29113469 [PubMed - in process]
Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research