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Could Fish Oil, Vitamin D Help Ease Lupus?

THURSDAY, Nov. 9, 2017 -- People with lupus may fare better if they have enough vitamin D and omega-3 fats in their diet, preliminary research suggests. In separate studies, researchers linked the two nutrients -- or lack thereof -- to higher risks...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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First bit of news: I’ve had absolutely no pain in my heel. It’s as good as new. I have to admit I’m still stunned…and I wonder if a more conventional doctor, let’s say a physiotherapist, would have made the connection between my relatively new eyeglass prescription and my heel pain. I doubt it. This makes me wonder how many similar cases there are, of people who think they have plantar fasciitis or tendonitis or, sorry for the mention!  , heel spurs, but whose pain actually originated in a different part of the body, an easy-to-fix part of the body. Mind-blowing, eh? But the reason I&rsq...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll celiac disease curcumin EBV Epstein-Barr virus inflammatory bowel disease lupus multiple sclerosis rheumatoid arthritis type 1 diabetes Source Type: blogs
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease characterized by the loss of tolerance against nuclear autoantigens in which the production of autoantibodies leads to tissue damages through the formation and deposition of immune complexes. Recent genome-wide association studies of SLE patients have revealed that polymorphisms of interferon regulatory factor (IRF) 7 and IRF8 are associated with an increased risk of SLE but the precise role of these IRFs in SLE development is not fully understood.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by impaired T lymphocyte homeostasis, resulting in increased apoptosis and T cell hyperactivation. A wealth of studies has implicated autophagy in the pathogenesis of SLE. However, the mechanisms underlying the regulation of autophagy and apoptosis in SLE remain unclear. The aim of this study was to explore the role of miR-3926 in crosstalk of autophagy and apoptosis in SLE. By qRT-PCR and western blot, we found that the expression of miR-3926 was significantly up-regulated in SLE CD4+ T cells compared with in healthy donors and was inversely ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
There is increasing interest in the potential involvement of lncRNAs in SLE etiology, owing to aberrant function of lncRNAs in cell proliferation, differentiation, apoptosis, development and immune responses. Aberrant expression of lncRNAs affect the function of moDCs and thus influence clinical diseases. The aim of our study was to explore lncRNA expression in moDCs of SLE patients to provide new insight into the pathogenesis of SLE. LncRNA and mRNA microarrays were performed to identify differentially expressed lncRNAs in moDCs of SLE patients compared with normal controls.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
Vitiligo is a chronic auto-immune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system. Interestingly, several studies observed increased anti-melanocyte antibodies in the sera of patients with vitiligo, suggesting the involvement of humoral immunity in disease pathogenesis. Follicular Helper CD4+ T (TFH) cells are specialized providers of B cell help for the production of antibodies and have been shown to play a central role in the pathogenesis of auto-immune diseases, such as systemic lupus disease.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
The Ro60 protein is a prominent autoantigen in systemic lupus erythematosus (SLE). Anti-Ro antibodies are strongly associated with photosensitivity in lupus. While it is known that Ro60 binds to small non-coding Y RNAs, it was recently reported that Ro60 also binds to Alu RNAs derived from short interspersed retroelements (SINEs). Loss of Ro60 in human cell lines resulted in the accumulation of Alu RNAs associated with an increase in type I interferon (IFN). Since SINE transcripts have been shown to be increased following DNA damage, we examined the relationship between Ro60, SINEs, and the inflammatory response after UV i...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
A hallmark of cutaneous lupus (CLE) is photosensitivity and induction of lesions by ultraviolet (UV) light in up to 93% of patients.  However, little is known about its biological mechanisms. Here we show that IFN-κ is a cutaneously expressed type I interferon (IFN), and one of two type I IFNs increased (FDR q
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
In this study, we use a database of cutaneous lupus erythematosus (CLE) patients to determine how many have a negative ANA and meet criteria for SLE using ACR and/or SLICC criteria. We used a database of 453 CLE patients that contained information including ANA status and the presence of features of SLE.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
OX40 is a costimulatory molecules predominantly expressed on T cells. Its ligand, OX40 ligand (OX40L), is predominantly expressed on antigen presenting cells. Some reports suggested the involvement of OX40L-OX40 axis in the development and exacerbation of lupus. However, it is still unknown if a blockade of OX40 signal can be a therapeutic option of lupus. To examine the effects of OX40 signal blockade in lupus, we used topical imiquimid (IMQ)-induced lupus model in WT and OX40L KO mice. We also used control IgG and anti-OX40L blocking mAb.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
A striking feature of many autoimmune diseases is their increased prevalence in females (e.g. systemic lupus erythematosus, female-to-male 9:1). With the female sex being the strongest known risk factor for autoimmunity, understanding the cause of female-biased susceptibility is critical to developing preventative measures. Previously, we demonstrated a female-biased molecular signature associated with susceptibility to autoimmunity, and identified VGLL3 as a female-biased factor that regulates this signature.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
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