Taxpayers pay twice for crucial drugs like Avastin | Letters

Big pharma companies are charging over the odds for medicines developed with public funding, writeHeidi Chow andTabitha HaIt is shocking, but not surprising, that big drugs companies are threatening to sue the NHS for using cheaper versions of drugs that could save people from going blind (Drug firms trying to stop cheap eye treatment on NHS, 1 November). Another part of this story is that the two medicines in question – Lucentis (known generically as ranibizumab) and Avastin (bevacizumab) are based on the groundbreaking discovery of monoclonal antibodies, whichwere developed with UK public funding.The NHS itself funded the trials to show that off-licence use of Avastin is as good as Lucentis, a finding that benefits patients not just in the UK but also globally. So the taxpayer is paying twice, first for public investment in the original research and clinical trials and then for the high prices being charged by the pharmaceutical companies. It is high time for conditions to be attached to publicly funded research and development to prevent these excessive profits and ensure crucial drugs are accessible and affordable for all.Heidi ChowGlobal Justice NowTabitha HaSTOPAIDSContinue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: NHS Drugs Medical research Science Health Society Pharmaceuticals industry Business Blindness and visual impairment Disability Source Type: news

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ConclusionPeople with RP and LCA have diverse attitudes toward gene editing technology informed by their own lived experience with disability, and many have concerns about how the ways in which it is discussed and implemented might affect them.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
P Sai Kiranmayee, Viswanath KalluriIndian Journal of Ophthalmology 2019 67(6):726-731 Many of the causes of childhood blindness are avoidable, being either preventable or treatable. Retinopathy of prematurity (ROP) remains one of the most preventable causes of childhood blindness worldwide. Currently, India is facing the third epidemic of ROP. In India, the health system involving the mother and child health services needs to be strengthened with a policy to cover the existing inadequacies in neonatal care and implementation of program covering newborn, especially premature. The access, availability, and affordability of ...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
AbstractPurpose of ReviewThis research aims to summarize evidence on the cardiovascular effects of indoor air pollution (IAP) from solid fuel and identify areas for research and policy for low- and middle-income countries.Recent FindingsIAP affects people from low socioeconomic status in Latin America, Asia, and Africa, who depend upon biomass as a fuel for cooking, heating, and lighting. In these settings, IAP disproportionately affects women, children, the elderly, and people with cardiopulmonary disease. The health effects of IAP include acute respiratory infections, chronic obstructive pulmonary disease, pneumoconiosis...
Source: Current Environmental Health Reports - Category: Environmental Health Source Type: research
CONCLUSIONS: This flourishing model helps to reimagine the clinician-patient relationship, and the methods and entire purpose of rehabilitation medicine, and clinical medicine more broadly. The condition of blindness is presented as an illustrative case. Implications for rehabilitation Amidst vast medical and technological advances in diagnosis and treatment of disabilities, modern health systems often still approach rehabilitation of disability via species-typical standards of bodily or mental homeostasis as the standard of sound health, without considering the perspectives and experiences of flourishing that are unique t...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Conclusion: Positive coping strategies are associated with a better QoL. Ophthalmologists who evaluate visual disability should consider coping mechanisms that their patients employ and should refer them for counseling and training in more positive ways of coping.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Conclusions: CBT, psychosocial intervention, supportive counseling, psychodynamic psychotherapy, and other psychological interventions can be recommended for clinical practice. More studies are needed, especially for non-CBT interventions and for all psychotherapies on negative symptoms.IntroductionSchizophrenia affects approximately 1% of the population, usually starting in adolescence or young adulthood, frequently leading to persistent disability, with a high risk of suicide (8%). Despite the advance in antipsychotics treatment, approximately 30% of patients with schizophrenia show a poor response or no response to anti...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Qi Li*, Zhaohua Lu, Ning Gao and Jingjing Yang School of Computer Science and Technology, Changchun University of Science and Technology, Changchun, China Objective: P300-speller is the most commonly used brain-computer interface (BCI) for providing a means of communication to patients with amyotrophic lateral sclerosis. However, the performance of the P300-speller BCI is still inadequate. We investigated whether the performance of P300-speller can be further improved by increasing the mental effort required of the user. Methods: We designed two active mental tasks for a P300-speller based on a differently colo...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
CONCLUSIONS: Significant challenges face individuals with disabilities as they use public transportation, and certain disability groups are more severely impacted by these problems. Implications for Rehabilitation Certain disability groups experience more severe problems with public transportation, as compared to other groups. Public policy advocacy and actions related to public transportation must prioritise individuals with disabilities who experience significantly more problems. Problems using public transportation for spontaneous activities pose increased problems for individuals with disabilities, and steps (i.e., ext...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
ier R Abstract BACKGROUND: In Usher syndrome, deafness is congenital and blindness is acquired. Therefore, the progressive loss of one of the two senses forces individuals with this syndrome to reorganize their everyday tasks and relationships, creating new strategies to communicate, access information, and move within a given space. This reorganization can interfere with the subjects' capacity to build a good quality of life. METHODS: We conducted a scoping review of both peer-reviewed and gray literature, to identify existing evidence of the role of psychosocial determinants on the quality of life of people...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
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