Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir

In conclusion, in rats, hypotension and lethality are associated with reduced arterial contractile function with ETx but not LTx and adefovir improves ETx-induced hypotension and lethality.
NEW & NOTEWORTHY The most important aspects of the present study are the findings that 1) in vivo challenge with anthrax edema but not lethal toxin depresses arterial contractile function measured both ex vivo and in vivo and 2) adefovir inhibits the effects of edema toxin on arterial hypotension and improves survival with lethal dose of edema toxin challenge.

Source: AJP: Heart and Circulatory Physiology - November 1, 2017 Category: Cardiology Authors: Suffredini, D. A., Li, Y., Xu, W., Moayeri, M., Leppla, S., Fitz, Y., Cui, X., Eichacker, P. Q. Tags: RESEARCH ARTICLE Source Type: research