Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials

Conclusions:
This study incorporated genetic data into past ALS trials to determine treatment effects in a genetic post hoc analysis. Our results suggest that we should reorient our strategies toward finding treatments for ALS, start focusing on genotype-targeted treatments, and standardize genotyping in order to optimize randomization and analysis for future clinical trials.

Source: Neurology - October 30, 2017 Category: Neurology Authors: van Eijk, R. P. A., Jones, A. R., Sproviero, W., Shatunov, A., Shaw, P. J., Leigh, P. N., Young, C. A., Shaw, C. E., Mora, G., Mandrioli, J., Borghero, G., Volanti, P., Diekstra, F. P., van Rheenen, W., Verstraete, E., Eijkemans, M. J. C., Veldink, J. H., Tags: Amyotrophic lateral sclerosis, Clinical trials Systematic review/meta analysis, All Genetics ARTICLE Source Type: research