Multilayered omics-based analysis of a head and neck cancer model of cisplatin resistance reveals intratumoral heterogeneity and treatment-induced clonal selection.

CONCLUSIONS: Our study demonstrates a link of intratumoral heterogeneity and clonal evolution as important mechanisms of drug resistance in SCCHN and establishes mutant GOF TP53 variants and the PI3K/mTOR pathway as molecular targets for treatment optimization. PMID: 29061642 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29061642?dopt=Abstract

Source: Clinical Cancer Research - October 23, 2017 Category: Cancer & Oncology Authors: Niehr F, Eder T, Pilz T, Konschak R, Treue D, Klauschen F, Bockmayr M, Türkmen S, Jöhrens K, Budach V, Tinhofer I Tags: Clin Cancer Res Source Type: research