Artesunate-Quercetin/Luteolin dual drug nanofacilitated synergistic treatment for malaria: A Plausible approach to overcome Artemisinin combination therapy resistance

Malaria is one of the major global health challenge with 300 million new cases annually. The best regimen for treating Plasmodium falciparum induced malaria is based on artemisinin and its derivatives which were prescribed as artemisinin combination therapy (ACT). These are highly effective drugs resulting in rapid clearance of parasites even in severe P. falciparum induced malaria patients. However, from the past few years parasites resistant to ACT ’s have begun to emerge in various parts of the world such as Cambodia and Greater Mekong Subregion.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research