Cutaneous Adverse Drug Reactions Caused By Antituberculosis Drugs.

Cutaneous Adverse Drug Reactions Caused By Antituberculosis Drugs.
Inflamm Allergy Drug Targets. 2014 Jul 17;
Authors: Rezakovic S, Pastar Z, Kostovic K
Abstract
Multidrug antituberculosis regimen is associated with diverse clinical patterns of cutaneous adverse drug reactions (CADR), ranging from mild and moderate such as pruritus, maculopapular exanthems, lichenoid eruptions, fixed drug eruptions and urticaria to severe and even life threatening ones like acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson syndrome and toxic epidermal necrolysis. These adverse reactions to antituberculosis drugs are commonly observed adverse events. This is of particular importance for high HIV prevalence settings and developing countries where tuberculosis is common infection resulting in higher occurrence rate of these reactions. There is still significant heterogenity in definition and classification of CADR, as well as diversity in treatment modalities following adverse reactions and rechallenge management. The aim of this review is to discuss clinical presentation, occurrence of CADR caused by antituberculosis drugs, to identify risk factors for intolerance of the standard therapy as well as to draw attention to importance of multi-disciplinary approach, early detection, prompt diagnosis and in time management of antituberculosis drugs associated CADR. CADR can cause significant treatment interruption and alteration, resulting i...

Source: Inflammation and Allergy Drug Targets - July 17, 2014 Category: Allergy & Immunology Authors: Rezakovic S, Pastar Z, Kostovic K Tags: Inflamm Allergy Drug Targets Source Type: research