Community-based statins and advanced carotid plaque: Role of CD163 positive macrophages in lipoprotein-associated phospholipase A2 activity in atherosclerotic plaque

Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzymatic inflammatory biomarker primarily bound to low-density lipoprotein cholesterol, is associated with an approximate twofold increased risk of cardiovascular disease and stroke. Despite indications that circulating Lp-PLA2 is sensitive to statins, it remains largely unknown whether statin usage exerts local effects on Lp-PLA2 expression at the site of atheromatous plaque.

Source: Atherosclerosis - October 13, 2017 Category: Cardiology Authors: Fumiyuki Otsuka, XiaoQing Zhao, Hugh H. Trout, Ye Qiao, Bruce A. Wasserman, Masataka Nakano, Colin H. Macphee, Martin Brandt, Sue Krug-Gourley, Liang Guo, Elena R. Ladich, Qi Cheng, Harry R. Davis, Aloke V. Finn, Renu Virmani, Frank D. Kolodgie Source Type: research