Log in to search using one of your social media accounts:

 

Growth inhibition of Candida species and Aspergillus fumigatus by statins.

Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins,simvastatin and atorvastatin, on five Candida species andAspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

Related Links:

Faraday Discuss., 2018, Advance Article DOI: 10.1039/C7FD00192D, PaperHirak Chakraborty, Md. Jafurulla, Andrew H. A. Clayton, Amitabha Chattopadhyay Photobleaching image correlation spectroscopy (pbICS) reveals that membrane cholesterol modulates the oligomeric state of the serotonin1A receptor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Faraday Discuss. latest articles - Category: Chemistry Authors: Source Type: research
Dalton Trans., 2018, Accepted Manuscript DOI: 10.1039/C7DT04403H, PaperDorota Loboda, Magdalena Rowinska-Zyrek The interaction between Pra1 zincophore and Zrt1 zinc(II) transporter is crucial for adequate Zn(II) acquisition in Candida albicans, the most common cause of fungal infections in humans. Pointing out the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
MILLIONS of healthy Britons are needlessly taking statins every day, a major review suggests. Experts last night raised concerns that those using the cholesterol-busting drugs see next to no benefit.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionsRegular statin use was not associated with pancreatic cancer risk in two large prospective cohort studies in the U.S.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Abstract ObjectivesThe aim of this study was to determine if spotty calcification decreases the response of plaque progression to statin therapy. BackgroundPrevious studies showed that the presence of spotty calcification is a marker of vulnerable plaque. However, the relationship between spotty calcification and plaque progression is not clear. MethodsNinety‐six nonculprit lipid‐rich plaques in 69 patients who received serial optical coherence tomography (OCT) imaging were included. Plaques were divided into three groups: spotty calcification (n = 38), calcified (n = 12) and noncalcified (n =&...
Source: Catheterization and Cardiovascular Interventions - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CAD ‐ CORONARY ARTERY DISEASE Source Type: research
Publication date: Available online 22 January 2018 Source:The Lancet Psychiatry Author(s): David Osborn, Alexandra Burton, Rachael Hunter, Louise Marston, Lou Atkins, Thomas Barnes, Ruth Blackburn, Thomas Craig, Hazel Gilbert, Samira Heinkel, Richard Holt, Michael King, Susan Michie, Richard Morris, Steve Morris, Irwin Nazareth, Rumana Omar, Irene Petersen, Robert Peveler, Vanessa Pinfold, Kate Walters Background People with severe mental illnesses, including psychosis, have an increased risk of cardiovascular disease. We aimed to evaluate the effects of a primary care intervention on decreasing total cholesterol concentr...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
AbstractSleep disturbances have been shown to be associated with adverse health outcomes including diabetes mellitus (DM), hypertension, and obesity. However, little is known about the relationship between sleep duration and diabetes complications. The present cross-sectional study aimed to examine the association between sleep duration and nephropathy in a population of type 2 DM patients. Diabetic patients aged ≥ 18 years who visited two outpatient clinics in Kermanshah from February 2014 to February 2015 entered the study. Demographic, anthropometric, and biochemical data, as well as information on sleep ...
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
Talking 'bout Trump's Cholesterol (and Yours, Too). What's worrisome (or not) when it comes to the numbers. by Kathleen Fifield, AARP, January 18, 2018| Comments: 0. lab worker holding a Cholesterol Ldl test tube. Getty Images. Doctors are starting to focus more on the "bad" cholesterol, otherwise known as LDL. Much of  ...
Source: AARP.org News - Category: American Health Source Type: news
The cholesterol-lowering agents known as statins have in vitro activities against human pathogenic fungi, such as Candida species, Cryptococcus neoformans, and Zygomycetes. Synergy between statins and azoles against these fungi has also been reported. We evaluated the in vitro activities of two statins, lovastatin andsimvastatin, alone and in combination with azoles and amphotericin B, against clinical isolates ofAspergillus spp.
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Abstract Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evaluate the metabolic stability, plasma protein binding, pharmacokinetics, toxicity, and efficacy of CD101 at various dose levels. CD101 was stable to biotransformation in rat/monkey/human liver microsomes and rat/monkey/dog/human hepatocytes. In vitro studies suggest minimal interaction with recombinant cytochrome P450 enzymes (IC50 values>10 μM). Similar to...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
More News: Aspergillus | Atorvastatin Calcium | Candida | Cholesterol | Lipitor | Respiratory Medicine | Simvastatin | Statin Therapy | Websites | Zivast | Zocor