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Effect of repeated administration of 4-methylpyrazole on renal function and lipid peroxidation products in rat kidney after ethylene glycol poisoning

Publication date: Available online 10 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Karina Sommerfeld-Klatta, Jędrzej Przystanowicz, Joanna Kowalówka-Zawieja, Barbara Zielińska-Psuja Toxic effects of ethylene glycol (EG) and its metabolites are mainly related to metabolic acidosis and kidney damage. EG biotransformation involving CYP2E1 affects the oxidant-antioxidant balance. The study assessed the effect of repeated administration of 4-methylpyrazole (4MP, 15mg/kg b.w. after 2hours, followed by 10mg/kg b.w. every 12hours) on renal function (creatinine, urea and urinary protein levels) as well as products of kidney’s lipid peroxidation (MDA and TBARS levels) in rats poisoned with EG (5745mg/kg b.w.). Serum EG and glycolic acid (GA) concentrations were measured throughout the experiment. Repeated administration of 4MP reduced the rate of EG elimination, extended the period of EG persistence in serum and significantly limited formation of GA. The study showed the temporary intensification of kidney oxidative processes that correlated with changes in kidney function. It was found that the use of 4MP in EG poisoning inhibited its biotransformation to toxic metabolites, but simultaneously intensified oxidative damages in kidneys.
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

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Publication date: 15 February 2018 Source:Chemical Engineering Journal, Volume 334 Author(s): Chi Fan, Zhen Chen, Lei Pang, Shujun Ming, Caiyue Dong, Kouadio Brou Albert, Peng Liu, Jingyu Wang, Dajian Zhu, Hanping Chen, Tao Li The resistances of Cu-SSZ-13 to hydrothermal aging and alkali metal poisoning for selective catalytic reduction of NOx with NH3 (NH3-SCR) were studied and comprehensive investigations were performed to better understand the poisoning mechanisms of the Cu-SSZ-13 catalyst. The NH3-SCR performance was well maintained after 700 °C hydrothermal aging for 12 h. With the aging temperature increasin...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
In a blockbuster investigation carried out along with the Washington Post, 60 Minutes’ Bill Whitaker looks into allegations that powerful pharmaceutical distributors helped advance the current opioid crisis by fulfilling patently suspicious orders for prescription opioids. The piece cites one example where a pharmacy in a West Virginia town with a population of several hundred ordered and received millions of opioid pills. The main source for the piece is Joe Rannazzisi, former head of the Drug Enforcement Agency’s Office of Diversion Control. Rannazzisi charges that as his office was planning to prosecute some...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical 60 minutes DEA drug enforcement agency opioid crisis washington post Source Type: news
Soft Matter, 2017, Accepted Manuscript DOI: 10.1039/C7SM01761H, PaperYongxiang Gao, Violet Alice Farkas, Roel P. A. Dullens, Dirk G. A. L. Aarts Confocal microscopy was used to directly observe the structural coarsening of the first layer of short colloidal rods sedimented onto a flat wall. Based on an image analysis algorithm we... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
Conclusions: The sharp increase in opioid-related stays overall during the transition to ICD-10-CM may indicate that the new classification system is capturing stays that were missed by ICD-9-CM data. Estimates of stays involving other diagnoses may also be affected, and analysts should assess potential discontinuities in trends across the ICD transition.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Introduction Although the majority of poisoning-related cases can be managed in home settings, reduction of hospital visits and admissions are still important challenge. Thousands of interventions are involved and the appropriate management of poisoning i...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
OBJECTIVES: Acute carbon monoxide poisoning is common and often severe. Domestic causes have been extensively documented, while occupational exposures have been reported less frequently. We analyse occupational carbon monoxide poisonings from the available...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news
October 24, 2017 12:00-1:30pm ET. You can also dial in using your phone: United States: +1 (646) 749-3131 Access Code: 532-687-157
Source: PHPartners.org - Category: International Medicine & Public Health Source Type: news
BACKGROUND: Pesticide self-poisoning is a major problem in Bangladesh. Over the past 20-years, the Bangladesh government has introduced pesticide legislation and banned highly hazardous pesticides (HHPs) from agricultural use. We aimed to assess the impact...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
Publication date: Available online 16 October 2017 Source:Catalysis Today Author(s): Mark E. Martínez-Klimov, Patricia Hernández-Hipólito, Marcos Martínez-García, Tatiana E. Klimova Palladium catalysts supported on hydrogen titanate nanotubes (HTN) were prepared by impregnation of palladium(II) acetate, characterized by N2 physisorption, powder X-ray diffraction, scanning electron microscopy, high-resolution transmission electron microscopy and tested in the Suzuki-Miyaura cross-coupling reactions between 4-bromobenzaldehyde and phenylboronic acid (reaction 1) or 4-hydroxyphenylboronic a...
Source: Catalysis Today - Category: Chemistry Source Type: research
(Natural News) If you were offered poison to eat, but were assured that scientists had added lots of beneficial vitamins and minerals to it, would you grab the opportunity to try some? Likely not, and yet that is what we as a society have been conditioned to do – just think of all those boxes...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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