Effect of repeated administration of 4-methylpyrazole on renal function and lipid peroxidation products in rat kidney after ethylene glycol poisoning

Publication date: Available online 10 October 2017 Source:Environmental Toxicology and Pharmacology Author(s): Karina Sommerfeld-Klatta, Jędrzej Przystanowicz, Joanna Kowalówka-Zawieja, Barbara Zielińska-Psuja Toxic effects of ethylene glycol (EG) and its metabolites are mainly related to metabolic acidosis and kidney damage. EG biotransformation involving CYP2E1 affects the oxidant-antioxidant balance. The study assessed the effect of repeated administration of 4-methylpyrazole (4MP, 15mg/kg b.w. after 2hours, followed by 10mg/kg b.w. every 12hours) on renal function (creatinine, urea and urinary protein levels) as well as products of kidney’s lipid peroxidation (MDA and TBARS levels) in rats poisoned with EG (5745mg/kg b.w.). Serum EG and glycolic acid (GA) concentrations were measured throughout the experiment. Repeated administration of 4MP reduced the rate of EG elimination, extended the period of EG persistence in serum and significantly limited formation of GA. The study showed the temporary intensification of kidney oxidative processes that correlated with changes in kidney function. It was found that the use of 4MP in EG poisoning inhibited its biotransformation to toxic metabolites, but simultaneously intensified oxidative damages in kidneys.
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

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Publication date: Available online 14 August 2018Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Diogo Vieira Tibery, Leandro Ambrósio Campos, Caroline Barbosa Farias Mourão, Steve Peigneur, Andréa Cruz e Carvalho, Jan Tytgat, Elisabeth Ferroni SchwartzAbstractTo1, previously named Tc49b, is a peptide neurotoxin isolated from venom of the scorpion Tityus obscurus that is responsible for lethal human poisoning cases in the Brazilian Amazonian region. Previously, To1 was shown to be lethal to mice and to change Na+ permeation in cerebellum granular neurons from rat brain. In addition...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
You're reading 4 Villains Lurking in the Dark – A Complete Guide to Handle Trolls and Haters, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are one of those people who is not scared to stick your neck out and take risks, then you are also one of those people who may get knocked down everyone once in a while. Whether, you’re a blogger who gets a tsunami of personal attacks when you post half an opinion, or an expert who runs a seminar and the participants start to criticize you. You may have even pit...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured relationships self improvement haters pickthebrain positivity trolls Source Type: blogs
“We often give our enemies the means of our own destruction.” – Aesop, The Eagle and the Arrow We can sometimes have difficulty accepting our friends, family, and loved ones as they are when their habits, quirks, or behavior annoy us. Our natural tendency is to try to change what we don’t like about them, which often leads to resentment. Nonetheless, given their importance and presence in our lives, we are usually willing to make an effort to accept them as they are. But what about people we dislike—people who cause us grief? For example, an overbearing boss, a scheming coworker, or an annoyin...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Publishers Self-Help Tiny Buddha acceptance Anger Boundaries Fear intentions Judgment reality Resentment Source Type: blogs
Nontherapeutic exposures to ADHD drugs range from inadvertent dosing to attempted suicide.Medscape Pediatrics
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pediatrics Viewpoint Source Type: news
Button battery ingestion is a big deal. So much so that The National Battery Ingestion Hotline (NBIH) was created in 1982 to study and advise best practices. They look at all types of batteries but swallowed button batteries account for 94% of batteries ingested. Until recently the agreed-upon first aid guidelines for a swallowed button battery were to take nothing at all by mouth (no oral intake!) but to get to the ER as soon as possible for timely x-rays to find the position of the battery, before promptly removing the battery with an endoscope. Who Swallows Button Batteries? Kids swallow button batteries, particularly k...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Dr. Greene's Blog Household Safety Toddler Health & Safety Source Type: blogs
A new study shows how an arsenic oxide, in combination with an existing drug, can cure leukemia, and it may be able to also treat other types of cancer.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Publication date: Available online 11 August 2018Source: Comparative Biochemistry and Physiology Part C: Toxicology &PharmacologyAuthor(s): Congqi Li, Muzi Zhang, Ming Li, Qian Zhang, Yunxia Qian, Rixin WangAbstractTriplicate groups of juvenile yellow catfish (1.98 ± 0.01 g) were fed diets supplemented with 0% and 1% alanyl-glutamine dipeptide (AGD) for 56 days under three ammonia concentrations (0.01, 5.70 and 11.40 mg L−1 total ammonia nitrogen). The results showed that ammonia poisoning could induce growth (weight gain and specific growth rate) and survival reduction, live ammonia and serum ...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - Category: Toxicology Source Type: research
Publication date: Available online 10 August 2018Source: Neurotoxicology and TeratologyAuthor(s): Takashi Yorifuji, Shigeru Takaoka, Philippe GrandjeanAbstractSevere methylmercury poisoning occurred in Minamata and neighboring communities in Japan during the 1950s and 1960s. A considerable number of children were born with conditions resembling cerebral palsy, later known as congenital Minamata disease. Although surviving patients are now in their 50s or 60s, few assessments of functional capacities in daily living have been performed. We assessed the changes in Activities of Daily Living (ADL) status of 11 patients over a...
Source: Neurotoxicology and Teratology - Category: Toxicology Source Type: research
In the last four years, there has been a surge in reports from poison control centers of Americans overdosing on tianeptine, an unapproved antidepressant with opioid effects, the CDC reports.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(University of Wisconsin-Madison) Some chemicals used to speed up the breakdown of plants for production of biofuels like ethanol are poison to the yeasts that turn the plant sugars into fuel. Researchers from the University of Wisconsin-Madison and several Department of Energy laboratories have identified two changes to a single gene that can make the yeast tolerate the pretreatment chemicals.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
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