CD4+ T helper cells and regulatory T cells in active lupus nephritis: an imbalance towards a predominant Th1 response?

In conclusion, the inverse association between Th1 cells from PBMC and urinary/renal tissue indicate a role for Th1 in LN pathophysiology. Urinary Th17 cells were associated with less severe LN, and Th17 increased in PBMC during therapy. Urinary CD4+ T cells were not different between LN and DC. The expression of the transcription factor Tbet in the glomerulus from a patient with active lupus nephritis. Th1 cells in peripheral blood are inversely correlated with urinary Th1 cells and with Tbet expression in renal tissue of patients with active lupus nephritis, whereas the Th17 response in urine is associated with a less severe course of the disease. Thus, the Th1 response seems to play a relevant role in the pathophysiology of lupus nephritis.
Source: Clinical and Experimental Immunology - Category: Allergy & Immunology Authors: Tags: Original Article Source Type: research