N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes

Conclusion Collectively, these results show that the diabetic blood and brain become progressively more susceptible to platelet activation and thrombosis. NAC, given after the establishment of diabetes, may offer protection against the risk for stroke by altering both systemic and vascular prothrombotic responses via enhancing platelet GSH, and GSH-dependent MG elimination, as well as correcting levels of antioxidants such as SOD1 and GPx-1. Graphical abstract
Source: Redox Biology - Category: Biology Source Type: research