Elderly adults show higher ventral striatal activation in response to motor performance related rewards than young adults

Publication date: 20 November 2017 Source:Neuroscience Letters, Volume 661 Author(s): Mario Widmer, Samara Stulz, Andreas R. Luft, Kai Lutz Feedback on motor performance activates the striatum and boosting ventral striatum activation with rewarding feedback during motor training supports the consolidation of the learned skill. Aging is associated with changes of the reward system, including striatal and extrastriatal loss of dopamine receptors. How these changes interact with the blood oxygenation level dependent (BOLD) response is, however, not yet fully understood. While it is known that reward prediction and reward-based decision-making differ between young and elderly healthy adults, the influence of age on the processing of rewarding feedback on motor performance have not been investigated so far. Nineteen young (26.42±2.84years) and 18 elderly (65.39±6.40years) healthy adults performed an arc-tracking task including performance feedback linked to a monetary reward after half of the trials, while undergoing functional magnetic resonance imaging (fMRI). The BOLD effect was compared in three predefined regions of interest: Ventral and dorsal striatum plus primary motor cortex. Our study demonstrates differences in the processing of motor performance related reward between young and elderly healthy adults. While both groups earned similar amounts of money linked to their own performance, the ventral striatal response to the rewarding feedback was higher in the older...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research