The Mitochondrial Pyruvate Carrier Mediates High Fat Diet-Induced Increases in Hepatic TCA Cycle Capacity

Conclusions By contributing to chronic hyperglycemia, fibrosis, and TCA cycle expansion, the hepatocyte MPC is a key mediator of the pathophysiology induced in the HFD model of T2D. Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research