Poster 59: Patient Characteristics Influencing Inpatient Rehabilitation Outcomes for Individuals with a Brain Tumor
Carrie Gould: I Have No Relevant Financial Relationships To Disclose
(Johns Hopkins Medicine) In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas.
In conclusion, FOXO4 possesses an anti-cancer glioma activity, which could be a novel target for future control of GBM.
Publication date: Available online 14 February 2020Source: Practical Radiation OncologyAuthor(s): Christopher S. Hong, Branden J. Cord, Adam J. Kundishora, Aladine A. Elsamadicy, Jason M. Beckta, Anita Huttner, Veronica L. Chiang, Charles C. MatoukAbstractRadiation necrosis (RN) is a well described complication seen after stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVM). First-line medical therapies are not always successful in alleviating symptoms and management of some cases may require open surgical resection of the lesion. Surgery is often thought of however as a last resort given its associa...
CONCLUSION: Our study was first to highlight the clinical significance of NEU count in GBM clinical treatment, which should be fully valued for clinical prediction and precise management. PMID: 32051739 [PubMed]
Publication date: Available online 14 February 2020Source: Journal of Neuroscience MethodsAuthor(s): Brittanie Partridge, John H. Rossmeisl, Alexandra M. Kaloss, Erwin Kristobal Gudenschwager Basso, Michelle H. TheusAbstractPrimary brain tumors are among the deadliest cancers that remain highly incurable. A need exists for new approaches to tumor therapy that can circumvent the blood brain barrier (BBB), target highly resistant tumors and cancer stem-like cells (CSCs) as well create an anti-cancer immunomodulatory environment. Successful treatments may also require a combinatory approach utilizing surgery, chemotherapy, ra...
Conclusions: Parents of children treated for BT report widespread and persistent deficits in executive functions that negatively affect their everyday functioning. Including analysis of all clinical scales and composite indices allows a more comprehensive approach and enables to specify the patients' executive profile. PMID: 32050813 [PubMed - as supplied by publisher]
This article details the study’s fascinating findings. My Patients Don’t Separate Their Physical and Mental Health. Medicare Must Stop Asking Us To: In this opinion article, a general practitioner in Melbourne, Australia shares her frustration over a new Medicare report that warns doctors against billing Medicare for both physical health and mental health issues within the same consultation. She argues that the rule essentially punishes practitioners who want to provide good-quality, holistic care for their patients. When Mental Illness Memes Stop Being Funny: Finding humor in our pain can be therapeutic, but c...
We examined lncRNA profiles from three glioma specimens using lncRNA expression profiling microarrays. Quantitative real-time RT-PCR was used to analyze the differential expression of raw intensities of lncRNA expression in glioma and peritumoral tissues. Results: We found 4858 lncRNAs to be differentially expressed between tumor tissue and peritumoral tissue. Of these, 2845 lncRNAs were up-regulated (fold change> 3.0) and 2013 were down-regulated (fold change 3.0) and 1804 that were down-regulated (fold change
Date: Friday, 02 28, 2020; Speaker: Duane Mitchell, M.D., Ph.D., Phyllis Kottler Friedman Professor, University of f\Florida Academic Health Center; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event