Cost ‐effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T‐cell acute lymphoblastic leukemia

ConclusionsLow frequency of DNMT3A mutations in pediatric T‐ALL is in striking contrast to adult T‐ALL and renders the necessity for the search of other candidate prognostic markers. Combined Sanger sequencing‐HRM approach offers a cost‐effective option for genotyping DNMT3A coding sequence, with potential clinical application in other hematological malignancies.This article is protected by copyright. All rights reserved.

Source: European Journal of Haematology - September 1, 2017 Category: Hematology Authors: Bronis ława Szarzyńska‐Zawadzka, Maria Kosmalska, Łukasz Sędek, Alicja Sonsala, Magdalena Twardoch, Jerzy R. Kowalczyk, Tomasz Szczepański, Michał Witt, Małgorzata Dawidowska Tags: Original Article Source Type: research