Regulation of Fibroblast Growth Factor 8 (FGF8) in Chicken Embryonic Stem Cells differentiation into Spermatogonial Stem Cells

This study further revealed the positive correlation between the expression level of FGF8 and MAPK/ERK signal. In the absence of FGF8, the expression of downstream genes such as FGFR2, GRB2, RAS, BRAF, RAF1 and MEK2 was not maintained, while overexpressing FGF8 enhances them. Thus, our study demonstrated that FGF8 can regulate germ cell fate by modulating the dynamic equilibrium between differentiation and self‐renewal, which provides a new idea for the study of germ cell regulatory network. This article is protected by copyright. All rights reserved

Source: Journal of Cellular Biochemistry - September 12, 2017 Category: Biochemistry Authors: Man Wang, Chen Zhang, Chuanli Huang, Shaoze Cheng, Nana He, Yilin Wang, Mahmoud F. Ahmed, Ruifeng Zhao, Jing Jin, Qisheng Zuo, Yani Zhang, Bichun Li Tags: Article Source Type: research