583 Sonodynamic therapy with 5-aminolevulinic acid for angiosarcoma

Angiosarcoma is a rare malignant tumor of vascular origin that represents 2% of all soft-tissue sarcomas. This highly aggressive tumor spreads widely through the skin, recurs locally and metastasis early. Sonodynamic therapy (SDT) with low-intensity ultrasound combined with a sonosensitizer may be a promising approach to cancer therapy. Sonosensitizers are known as 5-Aminolevulinic acid (5-ALA), bleomycin and photofrin, and others. The protocol of SDT has not been established. We investigated the feasibility of SDT for angiosarcoma with 5-ALA, a precursor of protoporphyrin IX in heme synthetic process.

Source: Journal of Investigative Dermatology - September 8, 2017 Category: Dermatology Authors: T. Ozawa, H. Furukawa, N. Noma, D. Tsuruta Tags: Melanoma and Other Skin Cancers Source Type: research