Malignant squamous cell carcinoma arising in a previously resected cerebellopontine angle epidermoid.
CONCLUSION: The imaging findings, histopathology, and management of a malignant SCC arising from a benign epidermoid cyst are discussed with recommendation for increased surveillance and follow-up, even for classically accepted benign lesions. PMID: 28868198 [PubMed]
ConclusionsThe nonphosphorylatable Y602 F-EPS8 and 4 F-EPS8 mutants decreased the expression of EPS8 downstream targets, as well as reducing tumor cell growth and motility, implying a crucial role for phosphorylation of EPS8, principally at Y602, in mediating protumorigenic signal transduction.
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): Noritaka Ohga, Jun Sato, Takuya Asaka, Kenji Hirata, Ken-Ichiro Sakata, Yohshima KitagawaObjectivesHypoxia is a common feature of cancer and, thus, is a prognostic factor for many types of cancer. Clinically, the prognosis of cancer with low oxygenation level is poor, and there is strong evidence that hypoxia in the tumor microenvironment is related to tumor angiogenesis and malignant progression. 18F-fluoromisonidazole (18F-FMISO) has been used in clinical and preclinical studies to provide s...
ConclusionsThe correlation of MIF with the severity of OM is compatible with the role of MIF as a proinflammatory protein. This seems to be the first study to describe this association; therefore, future prospective studies would be ideal to observe pre- and post-RT alterations in salivary MIF levels to validate this result and better understand the role of MIF in the pathogenesis of OM.
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): Rie Kawashima, Yoshinori Jinbu, Naruo Okada, Junichi Hayasaka, Tadahide Noguchi, Yoshiyuki MoriObjectivesOral potentially malignant disorders (OPMDs) have been suggested as oral precancers, including both oral precancerous regions and oral precancerous conditions. Oral squamous cell carcinoma (OSCC) is divided into 2 types according to the appearances of the cancerous regions. One type is carcinomas with precancerous white lesions—the sequential type. The other type is accompanied SCC wi...
ConclusionsOral mucosal manifestation of NHL is rare and, in most cases, the first sign of relapse. Many NHLs can present in oral soft tissues, and most are fatal, so clinicians should take NHL into consideration when making their differential diagnosis. NHL lesions can mimic periodontal disease, acute abscess, or even other malignancies.
Conclusions: Our results suggest that the role of regulating MUC1 and c-Met is related to invasion mechanisms by dysregulation of claudins and MMP activity.
ConclusionsOur data suggest that elevated levels of IL-4 and IL-9 may be associated with OSCC and potentially malignant disorders, indicating the possible participation of Th-2 and Th-9 cell subtypes in these conditions. Furthermore, elevated TNF-α levels observed in PLV group suggest an inflammatory process that possibly benefits tumor development. This could be a significant tool for distinguish and monitoring patients with PVL.
ConclusionsThe use of sunscreen was effective in the prevention of squamous cell carcinoma in lip, and the absent of follow-up care in patients with actinic cheilitis can influence the rates of malignization to squamous cell carcinoma, because the patients does not change the habits and the dentist cannot identify earlier the malignization of actinic cheilitis.
ConclusionsThe results reinforce the need to develop programs and preventive actions for oral cancer in western Santa Catarina, since the cases of SCC were diagnosed in advanced stage, affecting their quality of life, and disease-free survival time.
ConclusionsEosinophilic ulcer is likely a reactive painful lesion that mainly affects the tongue of adults, which may clinically mimic oral SCC.