Tablet and oral liquid L-thyroxine formulation in the treatment of na ïve hypothyroid patients with Helicobacter pylori infection

AbstractTo compare the clinical efficacy of tablet and oral liquid L-thyroxine (LT4) formulation in na ïve hypothyroid subjects withHelicobacter pylori infection. Forty-seven adult na ïve hypothyroid subjects with dyspeptic symptoms were investigated with upper endoscopy and divided into: 28 patients withHelicobacter pylori infection (Group A); 15 patients without gastric alterations (group B); 4 patients with autoimmune gastritis were excluded from the study. Subjects were randomly treated with a same dose of LT4 tablet (TAB) or oral liquid formulation (SOL), for 9 months on group A and 6 months on group B.Helicobacter pylori infection was eradicated after 3 months of LT4 treatment. On group A, after 3 months (beforeHelicobacter pylori eradication), subjects treated with SOL showed a greater thyroid-stimulating hormone reduction ( ΔTSH3 –0: TAB  = −4.1 ± 4.6 mU/L; SOL = −7.7 ± 2.5 mU/L;p = 0.029) and a greater homogeneity in the thyroid-stimulating hormone values (TSH3mo: TAB  = 5.7 ± 4.9 mU/L; SOL = 4.1 ± 2.0 mU/L;p = 0.025), compared to LT4 tablet. At 9 months (after 6 months ofHelicobacter pylori eradication) mean thyroid-stimulating hormone values were lower in subjects treated with LT4 tablet (TSH9mo: TAB  = 1.8 ± 1.2 mU/L; SOL = 3.2 ± 1.7 mU/L;p = 0.006). On group B no difference were observed, at each time point, in the mean thyroid-stimulating hormone values and thyroid-stimulating...
Source: Endocrine - Category: Endocrinology Source Type: research