RNAi-mediated ephrin-B2 silencing attenuates astroglial-fibrotic scar formation and improves spinal cord axon growth.

CONCLUSIONS: These results suggest that astroglial-fibrotic scar formation and particularly the expression of aggrecan and versican could be mitigated by ephrin-B2 specific siRNA, thus improving the microenvironment for spinal axon regeneration. PMID: 28834283 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28834283?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - August 21, 2017 Category: Neuroscience Authors: Li Y, Chen Y, Tan L, Pan JY, Lin WW, Wu J, Hu W, Chen X, Wang XD Tags: CNS Neurosci Ther Source Type: research