Loss of cutaneous large and small fibers in naive and L-dopa-treated PD patients

Conclusions:
Both large and small fiber pathology occurs in the early stages of PD and may account for the sensory and autonomic impairment. l-Dopa affects the 2 populations of fibers differently.

Source: Neurology - August 21, 2017 Category: Neurology Authors: Nolano, M., Provitera, V., Manganelli, F., Iodice, R., Stancanelli, A., Caporaso, G., Saltalamacchia, A., Califano, F., Lanzillo, B., Picillo, M., Barone, P., Santoro, L. Tags: Parkinson's disease/Parkinsonism, Neuropathic pain ARTICLE Source Type: research