Acromegaly is associated with increased cancer risk: a survey in Italy

It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18–1.68, P
Source: Endocrine-Related Cancer - Category: Endocrinology Authors: Tags: Research Source Type: research

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Authors: Pellino G, Gallo G, Pallante P, Capasso R, De Stefano A, Maretto I, Malapelle U, Qiu S, Nikolaou S, Barina A, Clerico G, Reginelli A, Giuliani A, Sciaudone G, Kontovounisios C, Brunese L, Trompetto M, Selvaggi F Abstract Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes. One out of five patients is diagnosed with metastatic CRC. The stage of diagnosis influences treatment outcome and survival. Notwithstanding the recent advances in multidisciplinary ma...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Publication date: Available online 28 June 2018Source: Journal of Molecular LiquidsAuthor(s): Shokoh Najafi, Saeid Amani, Mohsen ShahlaeiAbstractGemcitabine hydrochloride is an established chemotherapeutic agent in several solid tumors. Along with its outstanding effects, Gemcitabine has some side effects, which may cause suffering to patients. Herein we developed, a novel but simple method for the selective and sensitive quantitative determination of Gemcitabine drug based upon measuring the fluorescence quenching of functionalized Au doped quantum dots (QDs) in biological samples. The TGA capped Au doped CdTe quantum dot...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: 1 September 2018Source: Life Sciences, Volume 208Author(s): Cui Zhai, Wenhua Shi, Wei Feng, Yanting Zhu, Jian Wang, Shaojun Li, Xin Yan, Qingting Wang, Qianqian Zhang, Limin Chai, Cong Li, Pengtao Liu, Manxiang LiAbstractAimsIt has been shown that activation of autophagy is involved in the development of pulmonary arterial hypertension (PAH). Meanwhile, activation of nuclear factor-kappaB (NF-κB) has been found to induce autophagy in several types of human diseases including cancer and cardiac diseases. However, it is still unknown whether NF-κB mediates autophagy activation in PAH, and whethe...
Source: Life Sciences - Category: Biology Source Type: research
New York health officials are investigating after significant rates of leukemia, bladder, lung and thyroid cancers were found in three Long Island counties - 16 percent of all cases in New York state.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
SKIN cancer symptoms can be difficult to identify - even specialists can struggle to tell if a skin blemish is cancerous. So what signs should you be looking out for and when should you see your doctor?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
People who eat dinner before 9 p.m. -- or at least two hours before going to sleep -- have a 20% lower risk of breast and prostate cancer than those who eat after 10 p.m. or go to bed shortly after supper, researchers found.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
A longtime leader of the National Cancer Institute, he was known for his willingness to help anyone with a cancer diagnosis seeking advice or a referral.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Rabson, Dr. Alan Deaths (Obituaries) Cancer Research National Cancer Institute National Institutes of Health Kirschstein, Ruth Source Type: news
On a hunch, a doctor injected the Gardasil, the HPV vaccine, directly into the tumors of a woman with advanced skin cancer. The tumors disappeared. Nobody thinks it should be standard treatment, but it will spur more testing.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Authors: Moutia M, Habti N, Badou A Abstract Allium Sativum L. (garlic), which is a species of the onion family, Alliaceae, is one of the most used plants in traditional medicine worldwide. More than 200 chemicals with diverse properties have been found in garlic extracts. Several garlic compounds were suggested to be efficient in improving various pathologies including certain types of cancer. This paper is an overview of data about garlic biological activities in vitro and/or in vivo on immune cells, on the development of certain inflammatory diseases, and on different types of carcinomas and sarcomas. Garlic and...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
(MedPage Today) -- Across 17-year period, men twice as likely as women to die from the disease
Source: MedPage Today Nephrology - Category: Urology & Nephrology Source Type: news
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