Genome-wide DNA methylation variation in maternal and cord blood of gestational diabetes population

Gestational diabetes mellitus, (GDM) is defined as impaired glucose tolerance developed during pregnancy, of which the etiology is similar to that of type 2 diabetes mellitus, (DM) [1]. The prevalence of GDM ranges from 2 –10% in the United States, while a recent survey reported it to be 7.4% in Taiwan [2,3]. The population with GDM has been increasing worldwide owing to the epidemic of obesity, and its prevalence is elevated to 18% when the new criteria for diagnosing GDM is used [4]. Insulin resistance and hyperi nsulinemia can occur during pregnancy, which can lead to GDM in those without pregestational diabetes and those whose pancreatic function failed to overcome the diabetogenic environment during pregnancy [5].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research