Cell Therapy versus Lung Fibrosis

In recent years the research community has made some progress towards the use of cell therapies to treat fibrosis in lung tissue, the basis for a number of ultimately fatal conditions that present cannot be effectively controlled. Fibrosis is a disruption of the structure of tissue, the formation of scar-like structures that degrade tissue function. This line of research may soon be overtaken by the use of senolytic treatments to remove senescent cells, given that senescent cells appear to be a significant cause of the age-related failures in regenerative processes that cause fibrosis. Nonetheless, prior to recent work on cellular senescence and fibrosis, cell therapies were the most promising approach. Here, researchers report on recent progress in this part of the field: Promising research points towards a possible stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis. These diseases of the lung involve the buildup of fibrous, scar-like tissue, typically due to chronic lung inflammation. As this fibrous tissue replaces working lung tissue, the lungs become less able to transfer oxygen to the blood. In the case of IPF, which has been linked to smoking, most patients live for fewer than five years after diagnosis. The two drug treatments for IPF reduce symptoms but do not stop the underlying disease process. The only effective treatment is a lung transplant, whic...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

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Bone mineral density (BMD) has been positively associated with lung function in patients diagnosed with respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. However, t...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research
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Source: OnMedica Latest News - Category: UK Health Source Type: news
Authors: Friedlander HM, Ford JA, Zaccardelli A, Terrio AV, Cho MH, Sparks JA Abstract Introduction: Smoking is an established risk factor for both lung diseases and rheumatoid arthritis (RA). Chronic mucosal airway inflammation may result in immune tolerance loss, neoantigen formation, and production of RA-related autoantibodies that increase the subsequent risk of RA. In this review, we aimed to summarize the current evidence supporting the role of obstructive lung diseases and subsequent risk of RA.Areas covered: We identified scientific articles discussing the biologic mechanisms linking mucosal airway inflamma...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Introduction and Objectives: COPD is a small airway disease associated with ventilation heterogeneity. The LCI is more sensitive than FEV1 in cystic fibrosis however its place in COPD monitoring is unknown. We evaluated the use of the LCI among subjects with COPD comparatively to spirometry, BMI and exacerbation frequency. LCI can be time intensive and therefore we explored the potential of using a shortened LCI to 1/20th concentration.Methods: The LCI was measured by performing a Multiple Breath Washout using a modified photoacoustic Innocor device with 0.2% Sulphur Hexafluoride on subjects with COPD (N=84). The LCI was r...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Conclusion: The Aerobika* OPEP device was found to be acceptable for patients and therapists. Improvement in CAT scores were observed in 60% of COPD patients. Inclusion of the Aerobika* should be considered as an acceptable adjunct to ACT physiotherapy regimes for those with CF, bronchietasis or COPD
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Bronchiectasis can have different causes. Etiology impact on clinical and functional aspects is little known.Objectives: Identify causes of bronchiectasis non cystic fibrosis(BNFC) and investigate if there are differences concerning clinical, functional and of quality of life(QoL) among groups.Methods: Descriptive and cross-sectional study conducted in a Brazilian University hospital. Patients (N=109, mean age 53 yrs, 60% women) with tomographic diagnosis of bronchiectasis had medical files reviewed and were interviewed to identify personal and familial antecedents; they also performed spirometry and answered the Saint Geo...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Conclusion: Further studies are needed to characterize this group of patients in order to improve our clinical practice.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusions: In PAD with respiratory exacerbation, azithromycin prophylaxis reduced exacerbation episodes, additional courses of antibiotics, and risk of hospitalization. It should be considered as a valuable option to add azithromycin to usual treatment.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Acute critical care Source Type: research
This study aimed to produce iPSC-derived alveolar macrophages (iAM) using an established protocol for the production of iPSC derived macrophage progenitors. Briefly, progenitor cells were matured in conditioned media obtained from normal human lung fibroblasts (NHLF), BEAS-2-B or small airway epithelial cells (SAEC). Macrophage phenotype is known to be dependent on environmental signals, thus the use of conditioned media from lung cells is hypothesised to induce differentiation to iAM. These cells were characterised and compared to iPSC-derived microglia (iMGL) by flow cytometry, ELISA, ICC, phagocytosis and chemotaxis ass...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Molecular pathology and funct. genomics Source Type: research
Background: The diagnosis of Pseudomonas aeruginosa (PA) biofilms is not yet implemented in routine microbiology lab for Non Cystic Fibrosis (CF) Bronchiectasis (BE) alone or with Chronic Obstructive Pulmonary Disease (BE-COPD).Aim: To evaluate the early diagnostic of PA by applying recommended diagnostic methods for biofilm infections1 compared to standard methods.Methods: Prospective collection of sputum and serum samples every 3 months; Use of DTT (1:1) and sonication;>72h incubation, non-mucoid and mucoid PA isolation and MALDI-ToF. Gram-negative rods and PA biofilms imaging by Gram-staining and Fluorescent in situ ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
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