Thioredoxin-interacting protein induced α-synuclein accumulation via inhibition of autophagic flux: Implications for Parkinson's disease.

CONCLUSION: Our data suggested that TXNIP blocked autophagic flux and induced α-synuclein accumulation through inhibition of ATP13A2, indicating TXNIP was a disease-causing protein in PD. PMID: 28755477 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28755477?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - July 29, 2017 Category: Neuroscience Authors: Su CJ, Feng Y, Liu TT, Liu X, Bao JJ, Shi AM, Hu DM, Liu T, Yu YL Tags: CNS Neurosci Ther Source Type: research

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