CKII-SIRT1-SM22 α loop evokes a self-limited inflammatory response in vascular smooth muscle cells

ConclusionOur findings demonstrate that, in response to TNF- α stimulation, CKII-SIRT1-SM22α acts in a loop to reinforce the expression of SM22α, which limits the inflammatory response in VSMCsin vivo andin vitro. The anti-inflammatory effect of SIRT1 may be dependent on SM22 α to some extent. Our data point to targeted activation of SIRT1 in VSMCs as a promising therapeutic avenue in preventing cardiovascular diseases.
Source: Cardiovascular Research - Category: Cardiology Source Type: research