In vitro radical scavenging potential and toxicopathological implications of administration of aqueous leaf extract of Eucalyptus obliqua L.Her. (Myrtaceae) in Wistar rats

This study evaluated the in vitro antioxidant potential and toxicological effects of aqueous leaf extract ofEucalyptus obliqua via acute and 28-day once daily treatments in Wistar rats. In the acute toxicity test, rats were orally administered the extract up to 5000  mg/kg. The sub-chronic toxicity study was performed by once daily oral administration with the extract at 200, 400, 500, and 1000 mg/kg body weight for 28 days. The control rats received sterile distilled water. Biochemical and hematological indices were determined and a histopathological examin ation was carried out. The extract showed marked antioxidant effects that could be ascribed to its phytoconstituents. The LD50 was estimated to be>5000  mg/kg body weight. Except for the significantly modulated serum concentrations of high-density lipoprotein cholesterol, platelet and white blood cell counts, the extract revealed no significant (p >  0.05) effect on the biochemical and hematological indices in the treated animals compared to the control. Furthermore, there was no significant difference in weight gain of the treated rats and the control although there was a dose-dependent increase in food consumption of the extract-treated rats . These are indications of unlikely toxic tendency of the extract and were well supported by the no treatment-related infiltrations on the histoarchitectural features of the tissue sections of the investigated organs. Consequent upon these, the aq...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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In this study both experimental and theoretical methods were used to get insight into photophysical and photochemical properties of PTV with respect to its primary photochemistry. The PTV photodegradation quantum yield value was determined to be Ф = 0.011 (±0.002). PTV was found to undergo an intersystem crossing, however 3PTV* was formed with a low efficiency due partially to fluorescent properties exhibited by the statin. The lifetime of the excited singlet 1PTV* was calculated to be about 130 (±20) ps. 3PTV* was shown to be not involved in the formation of PTV primary photoproduct. Both PTV ...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
Authors: Sirtori CR, Ruscica M, Calabresi L, Chiesa G, Giovannoni R, Badimon JL Abstract Epidemiologically, high-density lipoprotein (HDL) cholesterol levels have been inversely associated to cardiovascular (CV) events, although a Mendelian Randomization Study had failed to establish a clear causal role. Numerous atheroprotective mechanisms have been attributed to HDL, the main being the ability to promote cholesterol efflux from arterial walls; anti-inflammatory effects related to HDL ligands such as S1P (sphingosine-1-phosphate), resolvins and others have been recently identified. Experimental studies and early c...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Authors: Infante T, Viscovo LD, Rimini ML, Padula S, Caso P, Napoli C Abstract Early identification of coronary atherosclerotic pathogenic mechanisms is useful for predicting the risk of coronary heart disease (CHD) and future cardiac events. Epigenome changes may clarify a significant fraction of this "missing hereditability", thus offering novel potential biomarkers for prevention and care of CHD. The rapidly growing disciplines of systems biology and network science are now poised to meet the fields of precision medicine and personalized therapy. Network medicine integrates standard clinical recording ...
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
ConclusionsHemodialysis patients with central obesity, as measured by the A/G ratio, had less favorable plasma lipid profiles and higher levels of inflammation but not an increased risk of ASCVD.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
This study aimed to investigate if statin use in cancer survivors was inversely associated with all-cause mortality.Methods and ResultsData from the 2002 to 2015 National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) were used. The Kaplan-Meier estimator was used to estimate the survival function according to statin usage. Cox proportional hazards regression models were adopted after stepwise adjustment for potential confounders to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality. The median follow-up duration was 10.0 years. Statin users had a higher percent...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
This study is registered with ClinicalTrials.gov, NCT02275780, and is closed to accrual.FindingsBetween Dec 1, 2014, and Oct 20, 2015, 1027 individuals were screened, of whom 769 participants were randomly assigned to doravirine (n=385) or ritonavir-boosted darunavir (n=384), and 383 in both groups were given at least one dose of their allocated treatment. Most participants were male (645 [84%] of 766) and white (560 [73%]), with a mean age of 35·2 years (SD 10·6). 292 participants in the doravirine group and 273 in the darunavir group completed 96 weeks of treatment. At week 96, a higher proportion of the do...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
This study tested the hypothesis that phenolic compounds can modulate the level of cholesterol transporters including Niemann-Pick C1-like 1 (NPC1L1) and ATP-binding cassette transporters in liver cells. HepG2 cells, used as a model of hepatocytes, showed a decrease in the abundance of cholesterol transporters comparatively to the control when treated with the Opuntia ficus-indica’s cladodes decoction. The decrease was between 13–70%, 25–60%, 9–60% and 23–60% for NPC1L1, ABCA1, ABCG5 and ABCG8 transporters, respectively, when using between 0.15 and 0.35 mg/mL of decoction in the culture medi...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Authors: Schlesinger A, Weiss A, Nenaydenko O, Koren-Morag N, Adunsky A, Beloosesky Y Abstract BACKGROUND: Statins and selective serotonin reuptake inhibitors (SSRIs) have beneficial effects on health outcomes in the general population. Their effect on survival in debilitated nursing home residents is unknown. OBJECTIVES: To assess the relationships between statins, SSRIs, and survival of nursing home residents. METHODS: Baseline patient characteristics, including chronic medications, were recorded. The association of 5-year survival with different variables was analyzed. A sub-group analysis of survival wa...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
ConclusionBoth neurologic and medical complications were common in majority of stroke patients. But the management protocol for stroke patients was sub-optimal and lagging behind the recommended guidelines due to lack of skilled personnel, appropriate treatment and diagnostic agents. The clinical team involved in the care of stroke patients should make preparations to take preventive measures that will save a lot of lives.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Publication date: Available online 14 November 2019Source: Microbial PathogenesisAuthor(s): Alaeldein M. Abudabos, Mashael R. Aljumaah, Manal M. Alkhlifi, Abdulaziz Alabdullatif, Gamal M. Suliman, Ali Ramzi AL SulaimanAbstractFree of Salmonella infection, a total of 600 broiler chicks (Ross 308) were randomly allotted to six dietary treatments (10 replicates) as follows: Negative control (only the basal diet); positive control (infected only); T1, infection + antibiotic (avilamycin); T2, infection + Bacillus subtilis and T3, Salmonella infection + Bacillus licheniformis. The results revealed t...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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