Disease progression in C9orf72 mutation carriers

Conclusions:
The pattern of scores of the ALSFRS-R, letter fluency, and FBI distinguished between ALS, ALS-FTD, and FTD presentations of C9orf72 mutation carriers and asymptomatic carriers. Longitudinal changes in these measures occurred with disease progression in a manner consistent with presenting phenotype.

Source: Neurology - July 17, 2017 Category: Neurology Authors: Floeter, M. K., Traynor, B. J., Farren, J., Braun, L. E., Tierney, M., Wiggs, E. A., Wu, T. Tags: Amyotrophic lateral sclerosis, Executive function, Frontotemporal dementia, All Genetics ARTICLE Source Type: research