Comparable impediment of cognitive function in female and male rats subsequent to daily administration of haloperidol after traumatic brain injury.
Comparable impediment of cognitive function in female and male rats subsequent to daily administration of haloperidol after traumatic brain injury. Exp Neurol. 2017 Jul 08;: Authors: Free KE, Greene AM, Bondi CO, Lajud N, de la Tremblaye PB, Kline AE Abstract Antipsychotic drugs, such as haloperidol (HAL), are prescribed in the clinic to manage traumatic brain injury (TBI)-induced agitation. While preclinical studies have consistently shown that once-daily administration of HAL hinders functional recovery after TBI in male rats, its effects in females are unknown. Hence, the objective of this study was to directly compare neurobehavioral and histological outcomes in both sexes to determine whether the reported deleterious effects of HAL extend to females. Anesthetized adult female and male rats received either a controlled cortical impact (CCI) or sham injury and then were randomly assigned to a dosing regimen of HAL (0.5mg/kg, i.p.) or vehicle (VEH; 1mL/kg, i.p.) that was initiated 24h after injury and continued once daily for 19 consecutive days. Motor function was tested using established beam-balance/walk protocols on post-operative days 1-5 and acquisition of spatial learning was assessed with a well-validated Morris water maze task on days 14-19. Cortical lesion volume was quantified at 21days. No statistical differences were revealed between the HAL and VEH-treated sham groups and thus they were pooled for each sex. HAL only impaired motor recover...
This video demonstrates a laparoscopic assisted transverse abdominis plane (TAP) block as an alternative to the traditional anesthesiology-driven ultrasound-guided TAP block to reduce postoperative pain.
To evaluate the feasibility and safety of laparoscopically assisted surgery for benign ovarian tumors via a single suprapubic incision under epidural anesthesia.
To evaluate the effect of intraoperative infiltration of liposomal bupivacaine on postoperative vaginal pain among patients undergoing pelvic reconstructive surgery including posterior colporrhaphy and/or perineorrhaphy.
To evaluate whether sub-cutaneous (SC) trocar site and intra-peritoneal (IP) anesthesia reduce post-operative pain.
To introduce a presacral nerve block for regional anesthesia in the pelvis.
Publication date: Available online 14 October 2019Source: Trends in Anaesthesia and Critical CareAuthor(s): Jack Stannus, Winston Cheung, Mark Kol, Rosalba Cross, Asim Shah, Atul Wagh, Nicola Clayton, Helen Wong
ConclusionsThe overall VTE rate after CABG has been low. However, the condition has been associated with worse 30-day postoperative outcomes and complications. The independent predictors of VTE development included a history of bleeding disorders, congestive heart failure in the 30 days before surgery, and operative time of ≥310 minutes. Understanding these risk factors should aid physicians in the decisions regarding prophylaxis and treatment.
AbstractPurposePerforated peptic ulcer (PPU) complicates 2 to 10% of patients with peptic ulcer disease and has mortality risk of up to 20%. Omental patch repair is the mainstay of surgical management and gastric resectional procedures are advocated for a large/giant ulcer or suspected malignancy. Emergency gastrectomy is associated with increased morbidity and mortality. The aim of this study is to compare the outcomes of omental patch repair with gastrectomy in patients with large PPU ( ≥ 20 mm).MethodsA retrospective review of all PPU patients who underwent surgery from January 2008 to December 2014 was d...
Despite the increased use of anesthesia services for endoscopic procedures in the United States, the risks of anesthesia-directed sedation (ADS) are unclear. We analyzed national data from multiple centers to determine patterns of use of anesthesia services and risk factors for serious complications.