Multiparametric Model for Penumbral Flow Prediction in Acute Stroke [Clinical Sciences]

In this study, we established a multiparametric perfusion imaging model and cross-validated it using positron emission tomography perfusion for detection of penumbral flow.Methods—In a retrospective analysis of 17 subacute stroke patients with consecutive magnetic resonance imaging and H2O15 positron emission tomography scans, perfusion maps of cerebral blood flow, cerebral blood volume, mean transit time, time-to-maximum, and time-to-peak were constructed and combined using a generalized linear model (GLM). Both the GLM maps and the single perfusion maps alone were cross-validated with positron emission tomography-cerebral blood flow scans to predict penumbral flow on a voxel-wise level. Performance was tested by receiver-operating characteristics curve analysis, that is, the area under the curve, and the models’ fits were compared using the likelihood ratio test.Results—The GLM demonstrated significantly improved model fit compared with each of the single perfusion maps (P
Source: Stroke - Category: Neurology Authors: Tags: Imaging, Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Contributions Source Type: research