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Interventions for the Treatment of Aromatase Inhibitor–Associated Arthralgia in Breast Cancer Survivors: A Systematic Review and Meta-analysis

Conclusion: The evidence was based on a body of research with moderate study quality. Although the overall effect of interventions is large, further investigation into the influence of nutrition and physical exercise is needed to better discern their potential for pain management. Implication for Practice: Oncology nurses may be able to implement such validated interventions as pain management modalities to mitigate the symptoms so that breast cancer survivors remain compliant with AIA therapy.
Source: Cancer Nursing - Category: Nursing Tags: Articles: Online Only Source Type: research

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This study shows that andrographolide inhibits the development of osteoclasts ( = the cells that chew away at our bones, which is fine in a healthy situation, not fine in cancer where everything goes nutso), while increasing the presence of osteoblasts (bone builders). The researchers say that the current therapies used to treat osteolytic diseases have many unwanted side effects. And they’re not just referring to bisphosphonates (which can cause osteonecrosis of the jaw) but also to new treatments such as the monoclonal antibody denosumab, Denosumab can cause low calcium levels, weakness, constipation, bac...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll Source Type: blogs
New research, which was presented at the American Association for the Advancement of Science’s annual conference, has found that moderate drinking is linked to a longer life. Drinking about two glasses of wine or beer a day was linked to an 18% drop in a person’s risk of early death—an even stronger effect than the life-preserving practice of exercise, according to the researchers. The results came from the 90+ Study, a research project out of the University of California Irvine’s Institute for Memory Impairments and Neurological Disorders that examines the habits of people who live to at least 90. ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime onetime Source Type: news
I have lots of aches and pain. This is a proven fact. You can ask any of my doctors. And I am also a klutz. And I have the battle scars to prove it.Last week, I tripped over my father's wheelchair in the waiting room of the chemotherapy department. How embarrassing. In front of maybe 40 people waiting for their appointments. They all noticed.This is what happened. We arrived at the hospital and my father grabbed a wheelchair. He has a bad leg so he pushes a wheelchair around instead of using a cane or walker. It's easier for him. He checked in for his appointment and we sat down to wait for him to be called. He parked the ...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: brainless cancer bonds falls klutziness more pain Source Type: blogs
SummaryLapatinib is a tyrosine kinase inhibitor used for the treatment of breast cancer. Paracetamol is an analgesic commonly applied to patients with mild or moderate pain and fever. Cancer patients are polymedicated, which involves high risk of drug interactions during therapy. The aim of the study was to assess the interaction between lapatinib and paracetamol in rats. The rats were divided into three groups of eight animals in each. One group received lapatinib + paracetamol (IL  + PA), another group received lapatinib (IIL), whereas the last group received paracetamol (IIIPA). A single dose of lapatinib ...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
AbstractBackground and purposeWe investigated the acute toxicity of accelerated partial breast irradiation using external beam (EB-APBI) or intraoperative radiotherapy (IORT) techniques in elderly breast cancer patients.Materials and methodsWomen  ≥ 60 years with unifocal breast tumors of ≤ 30 mm were eligible for this prospective multi-center cohort study. IORT was applied with electrons following lumpectomy (23.3 Gy). EB-APBI was delivered using 3D-CRT or IMRT in 10 daily fractions of 3.85 Gy within 6 weeks after surgery. Acut e toxicity was scored using the CTCAE v3.0 a...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusion According to our findings, NP (+) patients with BC had increased cardiac sympathetic activity, which was suggested to be associated with increased cardiovascular morbidity and mortality. PMID: 29447081 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Conclusion: The evidence shows that pilates or home-based exercise should be encouraged to women with breast cancer.Resumo Introdu ção: O câncer de mama é o principal tipo de câncer que causa morte em mulheres em todo o mundo. Estima-se que a doença cresça em razão do envelhecimento da população e dos fatores de risco relacionados ao comportamento e estilo de vida. Considerando o estilo de vida das mulheres com cânce r de mama antes ou após a cirurgia, o exercício de pilates pode ser uma intervenção complementar, alé...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
We present a patient with small bowel obstruction from distant metastasis of primary breast cancer. Each characteristic features of concern of GI tract distant metastasis from many pervious studies has been reported differently. We should remember that GI tract metastasis may coexist when patients with breast cancer have intermittent or recurrent abdominal pain with or without obstructive symptoms. PMID: 29441340 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
Abstract BACKGROUND AND OBJECTIVE: The high incidence of breast cancer in women has increased significantly in the recent years. Physician experience of diagnosing and detecting breast cancer can be assisted by using some computerized features extraction and classification algorithms. This paper presents the conduction and results of a systematic review (SR) that aims to investigate the state of the art regarding the computer aided diagnosis/detection (CAD) systems for breast cancer. METHODS: The SR was conducted using a comprehensive selection of scientific databases as reference sources, allowing access to ...
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Comput Methods Programs Biomed Source Type: research
History of trauma has been linked with increased pain and poorer pain outcomes in the chronic pain literature but less is known about how past trauma may impact post-surgical pain in breast cancer patients. Regression analysis was used to investigate the effect of prior trauma-related distress on pain interference, controlling for current pain intensity, cancer stage, age, and time since surgery; and whether current depressive symptomology intervenes on the relationship between past trauma-related distress and pain interference following surgery.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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